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Individualized mental disease prediction method and system adopting monkey-human interspecies migration based on brain function map

A mental disease and functional technology, applied in the field of bioinformatics and computational medicine, can solve the problems of lack of objective and effective diagnostic criteria in clinical diagnosis

Active Publication Date: 2019-03-29
CENT FOR EXCELLENCE IN BRAIN SCI & INTELLIGENCE TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, there is a lack of objective and effective diagnostic criteria for clinical diagnosis

Method used

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  • Individualized mental disease prediction method and system adopting monkey-human interspecies migration based on brain function map
  • Individualized mental disease prediction method and system adopting monkey-human interspecies migration based on brain function map
  • Individualized mental disease prediction method and system adopting monkey-human interspecies migration based on brain function map

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Experimental program
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Embodiment 1

[0141] In this example, taking the autism animal model of transgenic macaques as an example, a monkey-human transformable imaging study is carried out, so as to establish a method for predicting mental diseases.

[0142] The main process of the specific embodiment, the detailed steps are as follows:

[0143] Step S1: Using MeCP2 overexpression transgenic macaque (an animal model of non-human primate autism) to extract characteristic brain regions:

[0144] S11: Collecting resting-state functional magnetic resonance data of MeCP2 overexpression transgenic macaques and normal wild-type macaques samples by nuclear magnetic resonance scanner;

[0145] S12: According to the whole brain template with one-to-one correspondence between monkey and human brain regions, specifically, use the Regional Map template to divide the monkey cerebral cortex into 80 corresponding brain regions, and use the INIA19 template to divide the subcutaneous nuclei of the monkey brain into 14 brain region...

Embodiment 2

[0193] Performance Verification Experiment

[0194] In order to verify the performance of the method of the present invention, the method of the present invention (cynomolgus monkey) was compared with the prediction model based on the ASD data extraction characteristic brain region (ABIDEII) in the (ABIDE II) AutismBrain Imaging Data Exchange II public database. Among them, the ABIDE II data collection is marked as: the subjects use the ASD sample marks as the division standard of the experimental data.

[0195] This embodiment includes 62 ASD patients and 92 normal subjects. ASD data based on ABIDE II used group lasso to extract characteristic brain regions associated with autism pathology, including left superior temporal cortex (TCs), left secondary visual cortex (V2), left dorsal visual area anterior ( VACd), right primary motor cortex (M1), right anterior cingulate cortex (CCa), right central lateral prefrontal cortex (PFCcl), right ventrolateral prefrontal cortex (PFCvl...

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Abstract

The invention provides an individualized mental disease prediction method and system adopting monkey-human interspecies migration based on a brain function map. Specifically, the invention provides amethod for determining prediction models of mental disease. The method comprises the following steps: (a) obtaining data; (b) carrying out pretreatment; (c) selecting brain regions; (d) constructing features; (e) screening features; and (f) carrying out modeling and predicting. The method and the system provided by the invention have many advantages, including being noninvasive, high in accuracy,high in sensitivity, excellent in specificity, convenient to promote and so on.

Description

technical field [0001] The present invention relates to the technical fields of biological information and computational medicine, and more specifically to a method and system for individualized prediction of mental illness based on monkey-human cross-species migration of brain function maps. Background technique [0002] With environmental changes, accelerated pace of life, population aging and increasing social competition, brain developmental disorders (such as autism and mental retardation), mental diseases (such as depression, obsessive-compulsive disorder, anxiety disorder, etc.) Degenerative diseases (such as Alzheimer's disease and Parkinson's disease) are increasingly affecting the health of people of all ages in our country. The clinical diagnosis of this kind of mental illness mainly relies on behavioral scales to evaluate the patient's behavior. However, the clinical symptoms of mental illness are complex, and there is a large degree of overlap between the cognit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61B5/16A61B5/00
CPCA61B5/0033A61B5/0042A61B5/055A61B5/16A61B5/7271A61B5/4088A61B5/165A61B5/7267G16H50/20G16H30/40A61B5/4064G06F18/214
Inventor 王征詹亚峰
Owner CENT FOR EXCELLENCE IN BRAIN SCI & INTELLIGENCE TECH CHINESE ACAD OF SCI