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32 results about "Group lasso" patented technology

Psychosis automatic discrimination method based on multi-level feature fusion of functional connection networks

The invention proposes a psychosis automatic discrimination method based on multi-level feature fusion of functional connection networks, and the method comprises the steps: constructing the functional connection network by using resting-state functional nuclear magnetic (Rs-fMRI), calculating features of two levels: network attribute features and functional connection features, wherein the network attribute features include six network local attributes and six network global attributes; stacking all functional connection networks all functions to calculate an average network, reserving a certain proportion of edges, and taking the correlation of the reserved positions as the features of the connection hierarchy; simplifying the features of two levels through the group Lasso with the consideration to the independence of brain regions and the correlation between features, and respectively constructing a support vector machine (SVM) classifier, and obtaining a final classification resultin a weighted voting mode. The method realizes automatic discriminant analysis of whether or not suffering from mental illness, and improves the accuracy of diagnosis of psychosis, and the method canbe applied to actual clinical diagnosis.
Owner:CENT SOUTH UNIV

Prokaryotic acetylation site prediction method based on information fusion and deep learning

The invention discloses a prokaryotic acetylation site prediction method based on information fusion and deep learning, and relates to the technical field of biological information. According to the prediction method, multi-information fusion is introduced, feature coding is carried out on protein sequences from multiple aspects of sequence information, physicochemical information and evolution information, and the difference between acetylation site and non-acetylation site protein sequences is fully reflected. The original special diagnosis space is screened and optimized by Group Lasso, important features of an acetylation site recognition model are reserved, the optimal feature subset is obtained, and the model calculation speed and quality are improved. The deep neural network generates features with discrimination through hierarchical learning of the optimal feature subset, the acetylation site and the non-acetylation site in the protein sequence are effectively distinguished, the calculation time is saved at the same time, other costs and related limitations are avoided, deep understanding of an acetylation molecular mechanism can be facilitated, and valuable reference information can be provided for experimental verification related to acetylation site recognition.
Owner:QINGDAO UNIV OF SCI & TECH

Evaluation method of excess sludge electroosmosis deep dehydration performance

The invention discloses an evaluation method of excess sludge electroosmosis deep dehydration performance, belonging to the technical fields of sewage treatment and solid waste treatment. The method comprises the steps of firstly, collecting a biological sludge sample, and measuring the initial moisture content (IMC), volatile solids (VSS), electrical conductivity (EC), pH value, zeta potential and extracellular polymeric substance (EPS) content of the sludge sample before electroosmosis dehydration is carried out; screening out the key indexes, i.e., EC, Z and EPS, which affect the electroosmosis deep dehydration performance, by using a Group Lasso model; establishing a regression equation based on the key indexes, and calculating according to the regression equation so as to obtain sludge moisture content (FMC) and dehydration rate (DR) after the electroosmosis dehydration is finished. The evaluation method can quantify a complex relationship between residual sludge properties and electroosmosis deep dehydration performance so as to obtain a better prediction result; the result is high in conformity with measured data of the FMC and the DR which are obtained after the electroosmosis dehydration of a simulation device is finished, so that the test work load is greatly reduced, and basis data is provided for further sludge modification.
Owner:NANJING UNIV

Recommendation method based on heterogeneous information network representation learning

The invention discloses a recommendation method based on heterogeneous information network representation learning, wherein the recommendation method comprises the steps: extracting information, carrying out representation learning on nodes in a heterogeneous information network, wherein the nodes comprise user nodes and project nodes; obtaining low-dimensional vectors of a user and a project; directly docking the low-dimensional vectors of the user and the project with a recommendation task, inputting the low-dimensional vectors as recommended sample features into a domain perception factorization machine model, and carrying out feature selection by adding a group lasso as a regular item to complete score prediction between the user and the project; and completing recommendation according to score prediction. The heterogeneous information network representation learning method based on the meta-structure and the dynamic truncation random walk is adopted, not only can simple linear semantics be captured, but also mining of a complex nonlinear structure can be in order, and the problem of information loss caused by structural defects of a meta-path is effectively solved; and irreversible information loss possibly caused in an information fusion stage is avoided.
Owner:SICHUAN UNIV

Multi-fault-feature identification method based on sparse multiperiod-group lasso

The invention discloses a multi-fault-feature identification method based on a sparse multiperiod-group lasso. The multi-fault-feature identification method comprises the following steps that an to-be-identified signal is analyzed so as to construct a binary periodic sequence b, based on a fault feature signal, the between-group sparse characteristic in period groups are presented to obtain a regularization term P (x;b) for promoting between-group sparseness in the period groups, and a sparse multiperiod-group lasso model is established based on discrimination of different fault feature frequencies; controlled optimization operators of a data fidelity term (please see the specifications for the formula) and the regularization term (please see the specifications for the formula) in the sparse multiperiod-group lasso model are constructed correspondingly, through decoupling of the controlled optimization operators, variables are separated, aiming at each controlled optimization operator,the closed-form solution optimized by the controlled optimization operator is established, through iteration, the closed-form solution corresponding to the controlled optimization operator of each fault is solved, and thus model solving is achieved; regularization parameters are set adaptively through simulation signal counting and analyzing, the adaptive solution of the algorithm is obtained through the parameters, and thus each fault is obtained through separation; and aiming at each fault obtained through separation, the fault type is identified through envelope analysis.
Owner:XI AN JIAOTONG UNIV

A multi-fault feature identification method based on sparse multi-period group lasso

The invention discloses a multi-fault-feature identification method based on a sparse multiperiod-group lasso. The multi-fault-feature identification method comprises the following steps that an to-be-identified signal is analyzed so as to construct a binary periodic sequence b, based on a fault feature signal, the between-group sparse characteristic in period groups are presented to obtain a regularization term P (x;b) for promoting between-group sparseness in the period groups, and a sparse multiperiod-group lasso model is established based on discrimination of different fault feature frequencies; controlled optimization operators of a data fidelity term (please see the specifications for the formula) and the regularization term (please see the specifications for the formula) in the sparse multiperiod-group lasso model are constructed correspondingly, through decoupling of the controlled optimization operators, variables are separated, aiming at each controlled optimization operator,the closed-form solution optimized by the controlled optimization operator is established, through iteration, the closed-form solution corresponding to the controlled optimization operator of each fault is solved, and thus model solving is achieved; regularization parameters are set adaptively through simulation signal counting and analyzing, the adaptive solution of the algorithm is obtained through the parameters, and thus each fault is obtained through separation; and aiming at each fault obtained through separation, the fault type is identified through envelope analysis.
Owner:XI AN JIAOTONG UNIV

A Grouping Method of Group Lasso Characteristic Based on Network Analysis

The invention discloses a method for clustering lasso cluster characteristics based on network analysis, which is mainly used for solving the clustering of related expressed genes in bioengineering and establishing a lasso cluster model by using the method. The method comprises the steps of firstly, dividing experimental data into a positive data set and a negative data set, and respectively establishing a weighting co-expression gene network (adjacent matrix) corresponding to the positive data set or the negative data set; secondly, determining important network modules respectively corresponding to a positive sample and a negative sample; thirdly, simplifying a positive sample network module by utilizing a negative sample network module according to the experiment background; finally, clustering the characteristics according to the simplified positive sample network module, and establishing a lasso cluster and a promotion model of the lasso cluster according to the clustering. According to the method disclosed by the invention, the characteristic clustering of the lasso cluster is successfully and organically combined with module selection of network analysis, the operation is easy, the clustering method can be applied to screening of related genes in liver regenerative cell proliferation, and the method has an important application value in simulating a cell proliferation process of complicated diseases such as liver cirrhosis and cancer and screening new drugs.
Owner:HENAN NORMAL UNIV

Genotype-phenotype association analysis method in multi-omics data based on small sample

ActiveCN113192556BSolve the problem that the eigenvalues ​​are too large to be effectively regressedImprove forecast accuracyBiostatisticsProteomicsGenotypeGene association
A small-sample-based genotype-phenotype association analysis method in multi-omics data is disclosed, which specifically includes the following steps: generating a weighted undirected gene association graph using protein networks and gene expression values, and using the SPICi clustering method to The undirected graph is clustered to generate gene clusters; the gene clusters are screened by the group Lasso method; the SNP clusters corresponding to the screened gene clusters are obtained through the eQTL data; each SNP cluster, the corresponding gene cluster and the phenotype It is constructed as a three-layer network class block, and the sparse partial least squares method is used for regression operation on the relationship between SNP and gene in each class block, and logistic regression is used for operation on the relationship between gene and phenotype; The results are averaged to obtain the final prediction result. The invention can solve the problem that the eigenvalue is huge and cannot be effectively returned under the condition of small samples in the three-layer network; the prediction accuracy rate is improved; the biological meaning is clearer; and the tissue specificity is considered.
Owner:NORTHWESTERN POLYTECHNICAL UNIV +1

A method for evaluating the performance of electroosmotic deep dewatering of excess sludge

The invention discloses an evaluation method of excess sludge electroosmosis deep dehydration performance, belonging to the technical fields of sewage treatment and solid waste treatment. The method comprises the steps of firstly, collecting a biological sludge sample, and measuring the initial moisture content (IMC), volatile solids (VSS), electrical conductivity (EC), pH value, zeta potential and extracellular polymeric substance (EPS) content of the sludge sample before electroosmosis dehydration is carried out; screening out the key indexes, i.e., EC, Z and EPS, which affect the electroosmosis deep dehydration performance, by using a Group Lasso model; establishing a regression equation based on the key indexes, and calculating according to the regression equation so as to obtain sludge moisture content (FMC) and dehydration rate (DR) after the electroosmosis dehydration is finished. The evaluation method can quantify a complex relationship between residual sludge properties and electroosmosis deep dehydration performance so as to obtain a better prediction result; the result is high in conformity with measured data of the FMC and the DR which are obtained after the electroosmosis dehydration of a simulation device is finished, so that the test work load is greatly reduced, and basis data is provided for further sludge modification.
Owner:NANJING UNIV

Small sample-based genotype and phenotype association analysis method in multi-omics data

ActiveCN113192556ASolve the problem that the eigenvalues ​​are too large to be effectively regressedImprove forecast accuracyBiostatisticsProteomicsGene associationProtein
The invention discloses a small sample-based genotype and phenotype correlation analysis method in multi-omics data. The method specifically comprises the following steps: generating a weighted undirected gene association graph by using a protein network and a gene expression value, and clustering the undirected graph by using an SPICi clustering method to generate a gene cluster; screening the gene clusters by using a group Lasso method; obtaining an SNP cluster corresponding to the screened gene cluster through the eQTL data; constructing each SNP cluster, the corresponding gene cluster and the phenotype into a three-layer network class block, performing regression operation on the association relationship between the SNP and the gene in each class block by adopting a sparse partial least square method, and performing operation on the association relationship between the gene and the phenotype by adopting logistic regression; and averaging the obtained prediction results of the blocks to obtain a final prediction result. The method can solve the problem that effective regression cannot be realized due to huge characteristic values under the condition of small samples in a three-layer network; wherein the prediction accuracy is improved, the biological significance is clearer and tissue specificity is considered.
Owner:NORTHWESTERN POLYTECHNICAL UNIV +1
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