This invention discloses a method, apparatus, and medium for multi-scale
wavelet analysis of brain networks based on manifold learning. Using T1-weighted MRI and DW-MRI images, combined with Desctrieux mapping and probabilistic
fiber tractography based on surface seeds, an initial
adjacency matrix is obtained. The average
adjacency matrix is calculated. Based on the node degree, betweenness,
PageRank, and assignment coefficient of the average
adjacency matrix, several nodes are selected from the
brain network. Masks at different scales are calculated on the nodes. Multi-scale wavelets are initialized. The eigenvectors of the
Laplacian matrix of the average adjacency matrix are solved using a
power iteration method to obtain the optimal multi-scale
wavelet.
Protein signals in the
brain network are projected onto this
wavelet to obtain new biomarker signals from the
brain network. Therefore, this embodiment of the invention uses manifold learning to calculate the mean of a brain network group, which better maintains the geometric topology of the network and, considering the hierarchical
modularity and centrality of network nodes, better uncovers some potential physiological and
pathological mechanisms in brain diseases.