The application discloses a multi-center depression recognition method and
system based on decoupling of cross-subject relationship networks, relates to the technical field of medical
image processing and
artificial intelligence diagnosis, and comprises the following steps: acquiring subject data of a plurality of collection centers, wherein the subject data comprises brain image data; constructing an initial individual
brain function network based on the brain image data; performing individual
brain network representation learning on the initial individual
brain function network to obtain a subject-level
brain network representation; and performing decoupling learning and joint optimization based on
disease-related and collection center-related cross-subject relationship networks, and then guiding iterative updating of the individual
brain network through a group-level
disease discrimination representation, so that the common characteristics related to depression can be better mined, the influence of the differences between the collection centers on
feature learning is weakened, the representation and discrimination ability of the model for
disease characteristics is improved, the model has more stable performance in a multi-center scene, and the generalization performance of cross-center data is improved.