Human embryo transplantation in-vitro simulation research platform

Abstract

The invention provides a human embryo transplantation in-vitro simulation research platform. The platform is characterized by comprising a uterine cavity model, a pressure sensor, a micro-injection pump, a camera, a tilting table, a measurement and control box and a computer; the uterine cavity model is a nearly-closed flat triangular container which is established based on uterine cavity data ofthe human body and filled with a high-viscosity medium; the pressure sensor detects the pressure of the uterine cavity model to ensure that the uterine cavity model is the closest to the uterine cavity environment of the human body; the micro-injection pump injects a transplanted carrier into the uterine cavity model, the camera is fixed above the tilting table, a shooting lens is kept parallel tothe uterine cavity model, and a movement trajectory after the transplanted carrier enters the uterine cavity is shot. The simulation platform is established in vitro to explore the movement trajectory and deposition position of an embryo entering the uterine cavity under different transplantation procedures and different uterine positions, the technical measures of embryo transplantation are improved, the relationship between embryo movement and liquid and gas movement is observed, and the movement condition of the embryo is truly reflected.

Description

technical field [0001] The invention belongs to the technical field of embryo transplantation. Specifically relates to an in vitro simulation research platform of human embryo transplantation. Background technique [0002] The incidence of infertility is increasing year by year, and in vitro fertilization-embryo transfer (IVF-ET) technology has become a widespread medical technology. Among them, transferring embryos into the mother's uterus is one of the key technologies, which has an important impact on whether the mother can successfully conceive. Since the embryo is invisible to the naked eye and cannot be traced after transplantation into the uterus, the current lack of systematic research on embryo transfer technology makes it difficult to find operational defects and even more difficult to improve. [0003] In 2004, the team led by Israeli scholar Eytan established a simple embryo transfer simulation system in vitro for the first time. The microinfusion pump pushed t...

AI Technical Summary

Problems solved by technology

For example, the environment of the uterine cavity model using glycerol as a medium is derived from the research basis of the viscosity coefficient of ewe uterine cavity fluid of 1000cp, but there is no exact data on the real viscosity coefficient and density of the human uterine cavity

In addition, the uterine cavity is a nearly closed space with a certain pressure, and its pressure will change with the injection of liquid during the ET process. It is not proved whether the simulation system can achieve similar pressure changes.

The most important thing is that no embryo simulant is placed in the research system. Although the embryo enters the uterine cavity together in a mixture of liquid and gas, the three will separate later, and the trajectories are not consistent. Only the movement of air bubbles and liquid represents the movement of the embryo. So the true path of the embryo's travel and where it was deposited is unknown

Images