Time-of-flight (TOF) PET image reconstruction using locally modified TOF kernels

A kernel and image technology, applied in the fields of medical imaging and image reconstruction, can solve problems such as expensive and reduce timing resolution, and achieve the effect of reducing errors and improving effective timing resolution.

Pending Publication Date: 2019-04-02
KONINKLJIJKE PHILIPS NV
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Problems solved by technology

Therefore, it is expected that timing resolution will continue to be redu...

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  • Time-of-flight (TOF) PET image reconstruction using locally modified TOF kernels
  • Time-of-flight (TOF) PET image reconstruction using locally modified TOF kernels
  • Time-of-flight (TOF) PET image reconstruction using locally modified TOF kernels

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[0021] In TOF PET, the timing resolution of the PET detector is sufficient to measure, at least roughly, the time difference Δt between the detections of two 511 keV gamma rays of a coincident pair emitted by an electron-proton annihilation event. This time difference translates to the distance along the LOR towards the first detection event (or, equivalently, away from the second detection event) according to Δd=cΔt, where "c" is the speed of light. Events at the isocenter have At=0. In practice, uncertainty about event timestamps implies uncertainty in Δt and therefore uncertainty in Δd. This uncertainty can be represented by a Gaussian localization curve (or more generally a TOF kernel distributed along the peak of the LOR) that is centered (i.e., with its mean value) and has a variance corresponding to the uncertainty of the timestamp. Conventionally, this variance is set based on the detector velocity and the LOR is constant for all TOF positions.

[0022] Another disa...

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Abstract

An imaging device (1) includes a positron emission tomography (PET) scanner (10) including radiation detectors (12) and coincidence circuitry for detecting electron-positron annihilation events as 511keV gamma ray pairs defining lines of response (LORs) with each event having a detection time difference at between the 511 keV gamma rays of the pair. At least one processor (30) is programmed to reconstruct a dataset comprising detected electron-positron annihilation events acquired for a region of interest by the PET scanner to form a reconstructed PET image wherein the reconstruction includesTOF localization of the events along respective LORs using a TOF kernel having a location parameter dependent on At and a TOF kernel width or shape that varies over the region of interest. A displaydevice (34) is configured to display the reconstructed PET image.

Description

technical field [0001] The following generally relates to the field of medical imaging, the field of positron emission tomography (PET), the field of image reconstruction, and the like. Background technique [0002] Image reconstruction is a key component in the development and application of advanced positron emission tomography (PET) imaging. Compared with non-time-of-flight (TOF) scanners, commercial TOF PET scanners have improved lesion detection capabilities, reduced scan time or injection dose, and more accurate and precise measurements of lesion uptake. In TOF PET, the difference in arrival time of two photons is measured, which helps localize events along the line of response (LOR). This positioning uncertainty is determined by the system's compliance with the timing resolution. Assume that the most likely positions of events derived from this timing difference follow a Gaussian distribution (or more generally, the TOF kernel could be a Gaussian or some other distr...

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Application Information

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IPC IPC(8): G06T11/00
CPCG06T11/006G06T2211/416G06T7/0012G06T2207/10081G06T2207/10088G06T2207/10104G06T2207/10132G06T2211/421G06T2211/424
Inventor Y-M·朱A·安德烈耶夫S·M·科绍夫
Owner KONINKLJIJKE PHILIPS NV
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