Preparation method of radix angelicae pubescentis formula granules
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A formula granule and unique technology, applied in separation methods, pharmaceutical formulations, chemical instruments and methods, etc., can solve problems such as the unseen unique formula granules, and achieve the effect of improving the physical dissolution and transfer rate, reducing degradation and damage, and preventing the growth of microorganisms.
Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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Problems solved by technology
At present, there is no report on the preparation of Duhuo formula granules by continuous dynamic countercurrent water extraction process
Method used
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Embodiment 1
[0045] A preparation method of unihuo formula granules, comprising the steps of:
[0046] a. Selecting the lovage medicinal materials, vibrating sieve to remove impurities, washing with water, and drying at low temperature to obtain lovage decoction pieces, and then crushing them into 0.5cm coarse particles with a crusher;
[0047] b. Wet the coarse particles with 2 times the amount of water, and continuously input the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port at the front end, and pass through a set of spiral structures in the extraction tube. Continuously push the material forward to the slag outlet of the extraction tube to discharge the slag, and continuously add 16 times of 95°C hot water at the end of each level of extraction tube for continuous countercurrent extraction for 2 hours, and the hot water and material flow in reverse to each level of extraction The front end of the pipe...
Embodiment 2
[0053] In step c, the combined extracts are not cooled down, directly sterilized in an ultra-high temperature instantaneous sterilizer (UHT) at 105°C for 20 seconds, and then concentrated under reduced pressure at 55-60°C to form a clear paste with a relative density of 1.04 ;
[0054] All the other are with embodiment 1.
Embodiment 3
[0056] In step b, the coarse particles are not wetted, and are continuously input into the leaching tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port at the front end, and the material is discharged through a set of helical structures in the leaching tube. Continuously push forward to the slag outlet of the extraction tube to discharge the slag, and continuously add 16 times of 95°C hot water at the end of each level of extraction tube for continuous countercurrent extraction for 2 hours, and the hot water and materials flow in reverse to the bottom of each level of extraction tube The liquid is discharged from the front end, the extract is collected, and the dregs of the lovage medicine are discharged; the input speed of the lovage pieces is 100kg / h, and the flow rate of adding hot water in reverse is 1600L / h;
[0057] All the other are with embodiment 1.
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Abstract
The invention discloses a preparation method of radix angelicae pubescentis formula granules. The preparation method comprises the steps: a, radix angelicae pubescentis medicinal materials are crushedor chopped into coarse granules; b, the coarse granules are continuously input into a continuous countercurrent extracting machine, hot water is continuously and reversely added into the tail ends ofall stages of extraction tubes, continuous dynamic countercurrent extraction is conducted, and extracting solutions, aromatic water and volatile oil are collected respectively; c, the extracting solutions are filtered, ultra-high-temperature instantaneous sterilization is conducted, and filter liquor is concentrated into clear paste; d, the collected radix angelicae pubescentis aromatic water andvolatile oil are ground and included through auxiliary materials, the proper amount of clear paste is added, even mixing is conducted, spray drying is conducted, and thus a radix angelicae pubescentis volatile oil inclusion compound is obtained; e, the clear paste is added into the auxiliary materials to be dissolved, and spray drying is conducted to obtain dry extract powder; and f, the dry extract powder and the radix angelicae pubescentis volatile oil inclusion compound are added into pharmaceutical adjunct, even mixing is conducted, dry granulating is conducted, and thus the radix angelicae pubescentis formula granules are obtained. The preparation method adopts production processes such as continuous countercurrent extracting, high-temperature instantaneous sterilization, volatile oil inclusion and spray drying, all the process parameters are researched, and thus the product quality of the radix angelicae pubescentis formula granules is improved.
Description
technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Duhuo formula granules. Background technique [0002] The solitary life is the dry root of Angelica pubescens Maxim.f.biserrata Shanet Yuan. Excavate when the seedlings just germinate in early spring or when the stems and leaves wither in late autumn, remove fibrous roots and sediment, bake until half-dry, pile up for 2 to 3 days, and then dry until completely dry after softening. [0003] Traditional Chinese medicine formula granules are made by extracting, concentrating, drying, and granulating single-flavored Chinese medicine decoction pieces. The quality level of traditional Chinese medicine formula granules is evaluated based on the consistency of the three major indicators: ointment yield, fingerprint or characteristic map, transfer rate (or content) of main active ingredients and standard decoction ...
Claims
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