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Subcutaneous embedding thread for treating epilepsy

A technology of implanting thread and epilepsy, which is applied in the field of biopharmaceuticals, can solve the problems of large side effects, systemic and gastrointestinal reactions, liver and kidney function damage, etc., and achieve the effects of slow degradation, less surgical pain, and long use time

Pending Publication Date: 2019-04-16
朱金光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral a large amount of western medicine has great side effects, great damage to the systemic and gastrointestinal tract reactions, as well as liver and kidney functions

Method used

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  • Subcutaneous embedding thread for treating epilepsy
  • Subcutaneous embedding thread for treating epilepsy
  • Subcutaneous embedding thread for treating epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] API:

[0123] Phenytoin 2.4kg, carbamazepine 1.2kg, lamotrigine 0.6kg;

[0124] Accessories:

[0125] Frozen phenytoin, carbamazepine and lamotrigine respectively at -15°C for 2 hours and then ultrafinely pulverized with a superfine pulverizer to obtain superfine powder; spray 0.5kg of dry ice as a coolant during the superfine pulverization process ; At least 90% of the micropowder particle size in the superfine pulverization is not more than 5 microns; superfine pulverization to obtain ultrafine powder for later use; put polylactic acid and polyethylene glycol into the reaction kettle, and heat at 100 ° C, while heating Stir for 3 hours, then add phenytoin sodium superfine powder and continue to stir for 0.5 hours. When the auxiliary materials in the reaction kettle are in a viscous state, add methylcellulose sodium and continue to stir for 1 hour, and finally add carbamazepine and Lamosan Oxyzine superfine powder, stir evenly to obtain a mixture, cool and air-dry th...

Embodiment 2

[0127] API:

[0128] API:

[0129] Phenytoin 1.5kg, carbamazepine 1.5kg, lamotrigine 0.5kg;

[0130] Accessories:

[0131] Sodium methylcellulose 0.5kg, polylactic acid 0.15kg, polyethylene glycol 0.25kg.

[0132] Frozen phenytoin, carbamazepine and lamotrigine respectively at -15°C for 2 hours and then ultrafinely pulverized with a superfine pulverizer to obtain superfine powder; spray 0.5kg of dry ice as a coolant during the superfine pulverization process ; At least 90% of the micropowder particle size in the superfine pulverization is not more than 5 microns; superfine pulverization to obtain ultrafine powder for later use; put polylactic acid and polyethylene glycol into the reaction kettle, and heat at 100 ° C, while heating Stir for 3 hours, then add phenytoin sodium superfine powder and continue to stir for 0.5 hours. When the auxiliary materials in the reaction kettle are in a viscous state, add methylcellulose sodium and continue to stir for 1 hour, and finally ad...

Embodiment 3

[0134] API:

[0135] Phenytoin 3.4kg, carbamazepine 0.9kg, lamotrigine 0.8kg;

[0136] Accessories:

[0137] Sodium methylcellulose 0.3kg, polylactic acid 0.25kg, polyethylene glycol 0.15kg.

[0138] Frozen phenytoin, carbamazepine and lamotrigine respectively at -15°C for 2 hours and then ultrafinely pulverized with a superfine pulverizer to obtain superfine powder; spray 0.5kg of dry ice as a coolant during the superfine pulverization process ; At least 90% of the micropowder particle size in the superfine pulverization is not more than 5 microns; superfine pulverization to obtain ultrafine powder for later use; put polylactic acid and polyethylene glycol into the reaction kettle, and heat at 100 ° C, while heating Stir for 3 hours, then add phenytoin sodium superfine powder and continue to stir for 0.5 hours. When the auxiliary materials in the reaction kettle are in a viscous state, add methylcellulose sodium and continue to stir for 1 hour, and finally add carbamazepine...

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Abstract

The invention discloses a subcutaneous embedding thread for treating epilepsy. The embedding thread is composed of raw material medicine including phenytoin sodium, carbamazepine and lamotrigine and ingredient medicine including sodium methyl cellulose, polylactic acid and polyethylene glycol. The embedding thread is a cylindrical embedding thread with a biodegradable material as a carrier, and the cylindrical embedding thread is prepared by mixing the biodegradable material and medicine for treating epilepsy. Compared with common monotonous medicine for treating epilepsy, the treatment effectof the embedding thread is better, the embedding thread is slowly degraded after being embedded for three years, the application time of the embedding thread is long, frequent surgical injection is not needed, and the surgical pain of a patient is reduced.

Description

technical field [0001] The invention relates to a subcutaneous slow-release drug implanting thread, which is implanted under the skin and treats corresponding diseases according to the pharmacological properties of drugs mixed in the implanting thread, specifically a long-acting antihypertensive flexible The subcutaneous implant thread is used for treating epilepsy and belongs to the field of biopharmaceuticals. Background technique [0002] At present, the treatment of epilepsy at home and abroad mostly relies on oral drugs for treatment. The drug has a short action time, and it needs to be taken orally once, twice, or three times a day, and most of them are western medicines. Oral a large amount of western medicine has great side effects, great damage to systemic and gastrointestinal tract reactions and liver and kidney function. The present inventor has developed a subcutaneous implant thread for the treatment of epilepsy, which is a cylindrical implant thread made of a...

Claims

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Application Information

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IPC IPC(8): A61K31/4166A61K31/55A61K31/53A61K9/00A61K47/38A61K47/34A61K47/10A61P25/08
CPCA61K47/10A61K47/34A61K47/38A61P25/08A61K9/0024A61K31/4166A61K31/53A61K31/55A61K2300/00
Inventor 朱金光朱军星
Owner 朱金光
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