Preparation method of carrier-free macrolide immunosuppressive drug nanoparticles

A technology of macrolides and immunosuppression, applied in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of uncertain carrier biological toxicity, cumbersome carrier preparation process, drug loading and encapsulation efficiency Low-level problems, to achieve the effect of solving potential toxicity, high drug loading efficiency, and improving water solubility
CN109646403AInactive Publication Date: 2019-04-19FUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUZHOU UNIV
Publication Date
2019-04-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of carrier-free macrolide immunosuppressive drug nanoparticles. The carrier-free macrolide immunosuppressive drug nanoparticles are self-assembled to form micromolecular carrier-free nanoparticles through a solvent exchange method, so that the water solubility of a macrolide immunosuppressive drug is effectively improved, and the concentration dependencyinhibits the growth of tumor cells. The method has the advantages that the operation is convenient, simple and practical, and the prepared nanoparticles are small in particle size, high in drug-loading efficiency and good in stability, thereby improving the availability of the macrolide immunosuppressive drug.
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Description

technical field

[0001] The invention relates to the field of biomaterials and nanotechnology, in particular to a preparation method for self-assembling hydrophobic drugs into carrier-free nanometer drugs. Background technique

[0002] According to the latest global cancer statistics in 2018, there are an estimated 18.19 million new cancer cases and 9.6 million cancer deaths worldwide. In China, about 10,000 people are diagnosed with cancer every day, and 7 people are diagnosed with cancer every minute. Therefore, effectively treating cancer has become an urgent problem in the medical field.

[0003] Immunosuppressants refer to drugs that can suppress the immune response of the body, and can inhibit the proliferation and function of macrophages related to the immune response, such as T cells and B cells, thereby reducing the antibody immune response. Immunosuppressants are currently mainly used for anti-rejection after organ transplantation and autoimmune diseases such as l...

Claims

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