4results about How to "Avoid Potential Toxicity" patented technology

The application discloses an implant device interface system capable of realizing rapid cell adhesion and controllable release, a method and application, and relates to the technical field of biomedical materials and tissue engineering. The interface system comprises a first reaction group fixed on the surface of an implant device and a second reaction group inserted into the membrane of target cells through a membrane anchoring molecule; the membrane anchoring molecule comprises a cleavable linker; the first and second reaction groups constitute a complementary system such as click chemistry or biological orthogonality. The system realizes rapid adhesion within 0.5-6 hours, the cell migration rate increases after 6 hours of triggering, and a monolayer is formed within 12-48 hours, the cell tight junction is enhanced, and the blood compatibility is good (hemolysis rate < 5%). The system is applicable to different materials and cell types, and is suitable for surface cell construction and biological integration improvement of small-diameter artificial blood vessels, vascular stents, catheters, valves and other devices.

This invention discloses a calcium phosphate ceramic particle-methacrylated gelatin hydrogel scaffold for osteoblasts pretreated with Tideglusib to enhance osteogenic differentiation, relating to the fields of biomedical engineering and bone tissue regeneration. It comprises osteoblasts pretreated with Tideglusib and activated, biphasic calcium phosphate ceramic particles, and a methacrylated gelatin hydrogel encapsulating the osteoblasts and ceramic particles. The preparation method includes: obtaining rat osteoblasts; seeding the osteoblasts onto the biphasic calcium phosphate ceramic particles; and pretreating the seeded biphasic calcium phosphate ceramic particles with Tideglusib solution to activate the Wnt signaling pathway and promote osteogenic differentiation. This invention exhibits excellent bone defect repair capabilities, good degradability and biocompatibility, provides necessary mechanical support, and has strong clinical translational potential.

This invention relates to an electroactive casein bio-ink, its preparation method, and its applications, belonging to the field of biomedical materials technology. The ink uses quaternized methacrylamide casein (QCMA) as its core component, combined with a photoinitiator and chondrocytes. The preparation method involves first introducing quaternization into the casein to introduce cationic groups, then grafting photosensitive double bonds via methacrylation, purifying the resulting QCMA powder, and finally compounding it with a photoinitiator and cells to form the ink. This bio-ink possesses both high transparency and rapid photocuring properties, making it suitable for high-precision DLP printing. The constructed hydrogel exhibits intrinsic ionic conductivity, enabling the reconstruction of the electrophysiological microenvironment of damaged tissues and acting as an "electric bridge." Simultaneously, its quaternary ammonium groups endow the material with broad-spectrum antibacterial capabilities and promote cell adhesion and matrix deposition. The material of this invention is applicable to tissue regeneration fields such as cartilage defect repair.

This invention discloses a method for preparing and applying right-handed molybdenum-doped carbon dots. The method involves using D-tartaric acid, ethylenediamine, and molybdenum salt as raw materials, followed by hydrothermal reaction, centrifugation, dialysis, and lyophilization to obtain D-Mo-CDs. These carbon quantum dots exhibit selective response to circularly polarized light; D-Mo-CDs are specifically activated under left-handed circularly polarized light irradiation, achieving a photothermal conversion efficiency of 51.2%, and possessing highly efficient reactive oxygen species generation capabilities, enabling photodynamic-photothermal synergistic antibacterial effects. This invention also discloses the application of these carbon quantum dots in the preparation of spatiotemporally precise antibacterial materials and in medical devices or dressings for treating bacterial infected wounds. This material exhibits high biocompatibility, significant in vitro antibacterial effects, and promotes wound healing in vivo, providing a novel integrated solution for the treatment of infected wounds.