Zine glycyrrhizale film for treating oral sore and its preparation method

Abstract

A zinc glycyrrhizate film for treating oral ulcer is composed of an adhesive layer prepared from zinc glycyrrhizate and matrix made of carboxymethyl cellulose sodium, polyvinyl alcohol and plasticizer, an a protective layer prepared from polyvinyl alcohol and plasticizer.

Description

technical field [0001] The invention relates to a licorice zinc film for treating oral ulcers and a preparation method thereof. Background technique [0002] Recurrent oral ulceration is the most common oral mucosal disease, and its prevalence rate is as high as about 20%. There are many factors for its pathogenesis, which are still unclear so far, and may be related to factors such as heredity, immune disorders, viral or bacterial infections, gastrointestinal diseases, nutritional deficiencies, and mental stress. The main treatment measures for oral ulcers include local treatment and systemic treatment. Because local treatment has the characteristics of small side effects and convenient application, it is often used in the treatment of oral ulcers. [0003] The dosage forms for local treatment of oral ulcers include ointments, pastes, gels, gargles, powders, ultrasonic atomizers, sprays, adhesive tablets, films, etc. Different dosage forms of drugs have different characte...

AI Technical Summary

Problems solved by technology

Ointments, pastes, gels, etc. are easy to apply, but they are greasy and have a bad taste; gargles can act on various parts of the oral cavity, especially for oral ulcers with many ulcers and large areas, but the action time is short; Powders are mostly a simple mixture of various drug ingredients and are easy to disperse; ultrasonic atomizers are used in hospitals and require special atomization equipment, which is inconvenient to use, but individualized administration can be achieved according to the condition; sprays are convenient to use, but contain The drug dosage is small and the action time is short; the adhesive sheet and the film are mostly made of bioadhesive materials as the carrier, which can make the drug localized to the ulcer site, the action time is longer, and the effect is better; the adhesive sheet has a large drug load and is easy to prepare , but harder; the film is thinner and more flexible, and can be cut and used according to the size of the ulcer surface

[0004] Most of the medical films produced in China for the treatment of oral mucosal ulcers are single-layer films, such as the compound chlorhexidine dexamethasone film of Xi’an Kanghua Pharmaceutical Factory, the lysozyme oral film and the propolis oral film of Beijing Zizhu Pharmaceutical Co., Ltd. , Henan Fangyuan Pharmaceutical Co., Ltd.'s sitosterol dyclonine film, these single-layer film melts completely in the mouth in a few minutes, and the action time of the drug is short