The invention provides an antibiotic anti-inflammatory health care mouth lotion prepared by forming a natural mixed base material from watermelon frost, sorbitol, peppermint essence, eucalyptus oil, huamel extract, boat-fruited sterculia seed raw juice, lemon extract, licorice and clove extract, and then adding a given amount of bamboo salt and auxiliary materials. The antibiotic anti-inflammatory health care mouth lotion is capable of thoroughly cleaning the oral cavity, cleaning the breath, protecting health of the oral cavity, cleaning the oral cavity and eliminating oral diseases, has antibiotic, sterilizing and anti-inflammatory functions, and has notable lasting curative effects on preventing canker sore, aphtha, gingivitis, intermittent toothache and tooth erosion, halitosis and other oral diseases. The mouth lotion also has strong detoxifying and toxin-expelling effects, does not generate secondary abnormal breath of oral cavity and mixed peculiar breath smell, can not form dental plaque and cause decayed tooth, and is very favorable for the physical and psychological health of people without any side effects on the body. Therefore, the mouth lotion has the effects on refreshing the mouth and brain, cleaning the oral cavity, eliminating inflammation and foul breath, promoting production of body fluid, cleaning the throat, moisturizing the intestines and stomach, and leaving a fragrant and lasting smell in the mouth.