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A kind of nanocomposite hydrogel dressing and its preparation method and application

A nanocomposite and hydrogel technology, applied in medical science, bandages, etc., can solve problems such as prone to inflammation, hinder wound healing, and bacterial drug resistance, so as to eliminate wound bacterial infection, promote infected wound repair, and improve The effect of antibacterial ability

Active Publication Date: 2022-06-24
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the overuse of antibiotics has led to bacterial resistance, and the rise in mortality from the proliferation of resistant strains has become a major public health concern
In addition, skin injuries are prone to inflammatory responses, leading to excessive production of reactive oxygen species (ROS) at the wound site, which seriously impedes wound healing.

Method used

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  • A kind of nanocomposite hydrogel dressing and its preparation method and application
  • A kind of nanocomposite hydrogel dressing and its preparation method and application
  • A kind of nanocomposite hydrogel dressing and its preparation method and application

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preparation example Construction

[0042] like figure 1 As shown, the preparation method of the present invention specifically comprises the following steps:

[0043] 1) Preparation of F127 aqueous solution. Add 9 mL of pure water and 2.2 g of F127 to the vial, ultrasonically shake it, and place it in a refrigerator at 0°C overnight until it is completely dissolved.

[0044] 2) Preparation of copper phytate nanoparticles. The F127 aqueous solution was placed in an ice-water bath for stirring, and 500 μL of sodium phytate with different concentrations was added. Subsequently, 500 μL of different concentrations of copper chloride aqueous solutions were added respectively, and the molar ratio of copper chloride to sodium phytate was 3:1. The final concentrations of sodium phytate in samples A, B, C, and D were 0%, 0.5%, 1.0%, and 2.0%, respectively, and the final concentration of F127 was 22%. After continuous stirring for 50 min, the pH of the reaction system was adjusted to 7.0-7.4 with 1 M NaOH solution.

...

Embodiment 1

[0056] 1) Preparation of F127 aqueous solution: 2.2 g of F127 was added to 9 mL of aqueous solution, sonicated and then placed in a refrigerator at 0°C overnight until completely dissolved.

[0057] 2) Preparation of copper phytate nanoparticles: the F127 aqueous solution was placed in an ice-water bath for stirring, and 500 μL (100 mg / mL) of sodium phytate was added dropwise. After stirring evenly, 500 μL of copper chloride aqueous solution containing 21.8 mg was added, and stirring was continued for 50 min. The molar ratio of copper chloride to sodium phytate was 3:1. The final concentration of sodium phytate in the sample was 0.5%, and the final concentration of F127 was 22%.

[0058] 3) Preparation of nanocomposite hydrogel: The pH of the reaction system was adjusted to 7.4 with 1M NaOH solution. Heating in a water bath at 37°C gradually changed the reaction system into a gel state, and the nanocomposite hydrogel dressing loaded with copper phytate was obtained, which wa...

Embodiment 2

[0060] 1) Preparation of F127 aqueous solution: 2.2 g of F127 was added to 9 mL of aqueous solution, sonicated and then placed in a refrigerator at 0°C overnight until completely dissolved.

[0061] 2) Preparation of copper phytate nanoparticles: the F127 aqueous solution was placed in an ice-water bath for stirring, and 500 μL (200 mg / mL) of sodium phytate was added dropwise. After stirring evenly, 500 μL of copper chloride aqueous solution containing 43.6 mg was added, and stirring was continued for 50 min. The molar ratio of copper chloride to sodium phytate was 3:1. The final concentration of sodium phytate in the sample was 1.0% and the final concentration of F127 was 22%.

[0062] 3) Preparation of nanocomposite hydrogel: The pH of the reaction system was adjusted to 7.4 with 1M NaOH solution. Heating in a water bath at 37°C gradually changed the reaction system into a gel state, and a nanocomposite hydrogel dressing loaded with copper phytate was obtained, which was n...

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Abstract

The invention discloses a nanocomposite hydrogel dressing and its preparation method and application. In the method, polyether F127 polymer aqueous solution is used as a reaction medium, and sodium phytate and copper chloride are added in a certain proportion; in an ice-water bath environment, Through the coordination assembly strategy of phosphate and copper ions, copper phytate gradually nucleates and grows, and is uniformly dispersed in the F127 aqueous solution; finally, the pH of the reaction system is adjusted to neutral, and the reaction solution is gradually transformed into a coagulated form by heating in a water bath. gel state, that is, the nanocomposite hydrogel is prepared. The preparation method of the nanocomposite hydrogel dressing proposed in the present invention is green and environment-friendly, the raw materials are safe, and the cost is low. The hydrogel dressing prepared by the method has excellent mechanical properties and biological activity. The excellent temperature sensitivity, injectability and self-healing properties of the nanocomposite hydrogel ensure that it can be applied in complex wound environments.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a nanocomposite hydrogel dressing and a preparation method and application thereof. Background technique [0002] Healthy skin is an effective barrier that protects internal organs from pathogens, UV radiation and other external threats. However, large-scale skin burns, severe traumatic injuries, surgical trauma or chronic diseases such as diabetic wounds are still challenging clinical problems. Open, moist, exudate-containing wounds provide a suitable environment for bacterial colonization, and bacterial infection is a major factor in delaying the wound healing process. In addition, the host's inflammatory response is a local protective response to injury and is critical for infection control at the wound site. However, when a wound is usually infected, the body will induce a large number of immune cells to gather here, produce excess reacti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0066A61L26/008A61L26/009A61L2300/216A61L2300/102A61L2300/404A61L2300/604C08L71/02
Inventor 雷波王怡丹
Owner XI AN JIAOTONG UNIV
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