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Preparation method of polymer micro-needle mold

A production method and polymer technology, which can be applied to household appliances, other household appliances, household components, etc., can solve the problems of high price, complicated process, poor structural design, etc., and achieve the effect of reducing cost and simple production method.

Inactive Publication Date: 2019-04-30
SHENZHEN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, in patent CN201610882818.X, laser etching technology is used to prepare microneedle array templates. This method requires the use of laser engraving machines and the design of template patterns. The process of preparing microneedle array templates is complicated, expensive, and poor in structural design. , and requires professionals to operate, which is not conducive to the development of microneedle mold preparation technology

Method used

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  • Preparation method of polymer micro-needle mold
  • Preparation method of polymer micro-needle mold
  • Preparation method of polymer micro-needle mold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Making PDMS microneedle mold

[0041] (1) Surrounding the needles of the 42-needle cosmetic microneedles to prevent leakage of the dripped polymer;

[0042] (2) Add 100 μL of PDMS prepolymer to the needle body surrounded by step (1);

[0043] (3) Bake at 80°C for 1.5h to cure the polymer;

[0044] (4) Add 20 μL of 1% (w / v) PVA solution on top of the cured PDMS polymer, bake at 80°C for 10 min, to form a PVA film on the PDMS (such as figure 2 shown);

[0045] (5) adding PDMS prepolymer to the microplate, vacuum degassing the air bubbles therein, slowly inserting the microneedles prepared in step (4) into the microplate, so that the PDMS prepolymer is filled with the microneedles;

[0046] (6) At this time, the entire microplate and the microneedles inserted into the microplate are placed in an oven for baking, and treated at 80°C for 1.5 hours;

[0047] (7) Take out the microneedle, and pull out the PDMS polymer placed at the end of the microneedle body p...

Embodiment 2

[0049] The only difference between this example and Example 1 is that in the step (2), 50 μL of PDMS prepolymer is added to the enclosed needle body.

Embodiment 3

[0051] The only difference between this example and Example 1 is that in the step (2), 200 μL of PDMS prepolymer is added to the enclosed needle body.

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Abstract

The invention provides a preparation method of a polymer micro-needle mold. The preparation method comprises the following steps that needle bodies of a rigid miniature vertebral array are adopted asmale molds; PDMS prepolymer with different size is added based on different length requirements for needle bodies; the PDMS prepolymer is baked so that the PDMS polymerizes and solidifies; a PVA or Plannick F127 solution with certain concentration is added on the solidified PDMS and then baking is conducted; the PDMS prepolymer is added on a microwell plate, and the processed needle bodies are inserted in the microwell plate; the whole microwell plate is placed in an oven for baking; and the needle bodies are taken down from the microwell plate, the PDMS prepolymer at the tail ends of the needle bodies are pulled out of the needle bodies perpendicularly, and the PDMS polymer micro-needle molds are obtained. A custom male mold is not required during the micro-needle mold preparation process, and therefore the cost can be lowered. The preparation method is simple and is high in adjustability, and micro-needle molds with different lengths can be prepared based on different requirements.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, in particular to a manufacturing method of a polymer microneedle mold. Background technique [0002] Microneedles are small, micron-scale devices composed of many protrusions, where the height and shape of such protrusions are determined by the fabrication process. Microneedles are applied to the skin in a manner similar to a transdermal patch and create pores in the stratum corneum in the micrometer range, allowing hydrophilic as well as macromolecular drugs to pass through the skin and mimicking the process of a hypodermic needle. Therefore, microneedles can be considered as a hybrid drug delivery system between a safe and convenient transdermal patch and an efficient subcutaneous injection. [0003] Materials currently used to make microneedles include metals, silicon and its oxides, glass and polymers. The brittle nature of silicon and metal microneedles limits the application of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C33/38B29C39/02
CPCB29C33/3842B29C39/003B29C39/02B29L2031/7544
Inventor 陈永丽张珝
Owner SHENZHEN POLYTECHNIC