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Products for predicting the risk of developing acute kidney injury in human subjects with acute myocardial infarction and uses thereof

A technique for acute myocardial infarction, acute kidney injury, used in the field of predicting whether a human individual with acute myocardial infarction will develop acute kidney injury

Active Publication Date: 2022-04-26
CHUNG GUNG MEDICAL FOUNDATION LINKOU BRANCH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Although there have been the above-mentioned literature reports, as far as the applicant knows, there is no literature or patent record so far that has revealed the association of miR-23a-3p and miR-145-5p with acute kidney injury

Method used

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  • Products for predicting the risk of developing acute kidney injury in human subjects with acute myocardial infarction and uses thereof
  • Products for predicting the risk of developing acute kidney injury in human subjects with acute myocardial infarction and uses thereof
  • Products for predicting the risk of developing acute kidney injury in human subjects with acute myocardial infarction and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0085] 1. Preparation of serum samples:

[0086] The blood collected from the patient was centrifuged at 2,000 rpm for 10 minutes at 4°C and the supernatant was collected, and the serum samples thus obtained were frozen and stored at -80°C until use.

[0087] 2. Statistical analysis:

Embodiment 1

[0089] Example 1. Correlation assessment of the expression level of miRNA in serum and the development of acute kidney injury in patients with acute myocardial infarction

[0090] A. Correlation assessment of the expression level of a single miRNA:

[0091] In this experiment, AMI + AKI - group and AMI + AKI + Serum miR-23a-3p, miR-24-3p, miR-127-3p, miR- The expression levels of 145-5p, miR-214-3p, and miR-494-3p were determined to assess whether the expression levels of these miRNAs could be used to predict the development of acute kidney injury.

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Abstract

The present invention relates to methods for predicting the risk of developing acute kidney injury in a human individual with acute myocardial infarction. The present invention discloses a kit for predicting whether a human individual with acute myocardial infarction will develop acute kidney injury, wherein the kit comprises a reagent for detecting the expression level of miRNA selected from A group consisting of: miR-23a-3p, miR-24-3p, miR-145-5p, and combinations thereof. The present invention also discloses the use of the reagent supply for detecting the expression level of miRNA for the preparation of a kit for predicting whether a human individual with acute myocardial infarction will develop acute kidney injury.

Description

technical field [0001] The present invention relates to a method for predicting whether a human individual with acute myocardial infarction will develop acute kidney injury. In particular, the present invention relates to a method of using the expression level of at least one of miR-23a-3p, miR-24-3p, miR-145-5p to predict whether a human individual with acute myocardial infarction will develop acute renal failure. method of injury. Background technique [0002] Acute kidney injury (acute kidney injury, AKI) is mainly induced by a variety of major diseases, and will cause rapid loss of kidney function, which will lead to many complications, including fluid overload, electrolyte imbalance (electrolyte imbalance), metabolic acidosis (metabolic acidosis) and uremia (uremia) and so on. In recent years, since the concept of cardiorenal syndrome (cardiorenal syndrome) was proposed, acute kidney injury induced by acute coronary syndrome (acute coronary syndrome, ACS) (for example...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/178G16B25/10C12Q2600/118G16B40/00G16B20/00G16B5/20C12Q2600/106
Inventor 褚柏显张玉生陈嘉君范佩君
Owner CHUNG GUNG MEDICAL FOUNDATION LINKOU BRANCH
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