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Early warning method and system for acute kidney injury after extracorporeal circulation cardiac surgery

A technology for acute kidney injury and heart surgery, applied in health index calculation, medical simulation, medical automated diagnosis, etc., can solve the problems of early diagnosis of AKI in the research stage, early warning system included in the early warning system, etc., to increase accuracy and sensitivity , high degree of fitting, and high prediction accuracy

Inactive Publication Date: 2021-07-27
NANJING MEDICAL UNIV
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Problems solved by technology

[0008] In summary, the biological indicators for the early diagnosis of AKI are still in the research stage due to the influence of proteinuria, systemic state, and urinary system infection, which makes the early diagnosis of AKI after CPB difficult. The early warning system of post-AKI is also in the research and development stage, and there is no related early warning system that incorporates new biomarkers to improve the sensitivity of the early warning system

Method used

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  • Early warning method and system for acute kidney injury after extracorporeal circulation cardiac surgery
  • Early warning method and system for acute kidney injury after extracorporeal circulation cardiac surgery
  • Early warning method and system for acute kidney injury after extracorporeal circulation cardiac surgery

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Embodiment 1

[0042] Such as figure 1 As shown, the present embodiment provides a method for early warning of acute kidney injury after cardiopulmonary bypass cardiac surgery, which includes the following steps:

[0043] Step 101. Obtain the preoperative age, preoperative height, blood urea nitrogen level value on the day of operation, and urinary ATF3 level value corresponding to 12 hours after operation of the patient undergoing cardiopulmonary bypass surgery.

[0044] Activator of transcription 3 (ATF3), which is a member of the ATF / CREB subfamily of the basic-region leucine zipper (bZIP) family, can participate in the inflammatory response of sepsis. susceptibility plays an important role. ATF3 protects the heart in response to hypertensive stimulation in cardiac fibroblasts by inhibiting Map2K3 expression and subsequent p38 transforming growth factor-β signaling.

[0045] In this example, it was found through observation that blood and urine creatinine increased at different time poi...

Embodiment 2

[0062] Such as Figure 4 As shown, the present embodiment provides a method for early warning of acute kidney injury after cardiopulmonary bypass cardiac surgery, which includes the following steps:

[0063] Step 201. Obtain the preoperative age, preoperative height, blood urea nitrogen level value on the day of operation, and urinary ATF3*Kim-1 level value corresponding to 12 hours after operation of the patient undergoing extracorporeal circulation cardiac surgery, wherein the urinary ATF3 *Kim-1 level value represents the level value after multiplying the urine ATF3 level value 12 hours after operation by the urine Kim-1 level value 12 hours after operation.

[0064] Combined with blood urea nitrogen level is one of the risk factors for AKI, patients with high blood urea nitrogen are more likely to have kidney damage and increase ATF3.

[0065] Combined application of urinary ATF3*Kim-1 can increase the accuracy and sensitivity of early diagnosis of acute kidney injury in ...

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Abstract

The invention discloses an early warning method and system for acute kidney injury after extracorporeal circulation cardiac surgery. The early warning method comprises the steps: acquiring the preoperative age, the preoperative height, the urea nitrogen level value on the day of surgery and the urine ATF3 level value 12 hours after the surgery of a patient suffering from the extracorporeal circulation cardiac surgery; carrying out dimension normalization on the age before operation, the height before operation, the urea nitrogen level value on the day of operation and the urine ATF3 level value 12 hours after operation; taking the normalized preoperative age, the normalized preoperative height, the normalized urea nitrogen level value on the day of the operation and the normalized urine ATF3 level value 12 hours after the operation as variables, and establishing a disease prediction model of the cardiac postoperative acute kidney injury; and calculating and outputting the incidence prediction probability of the cardiac postoperative acute kidney injury. Independent risk factors (preoperative age, preoperative height, urea nitrogen level value on the day of operation and urine ATF3 level value of 12 hours after operation) of AKI are used as variables to construct an early warning model of acute kidney injury, and the prediction accuracy is high.

Description

technical field [0001] The invention relates to the technical field of acute kidney injury after cardiac surgery with extracorporeal circulation, in particular to an early warning method and system for acute kidney injury after cardiac surgery with extracorporeal circulation. Background technique [0002] Acute kidney injury (acute kidney injury, AKI) refers to the sudden decline in renal function, and is the most common complication of non-cardiac organs after cardiopulmonary bypass (CPB) cardiac surgery, with an incidence ranging from 30% to 59%. , the fatality rate of critically ill patients is as high as 50.0%. Studies in the past 20 years have found that although CPB technology, cardiac surgery technology, and postoperative monitoring technology have been continuously developed, the incidence of AKI is still high. Acute kidney injury after cardiac surgery not only affects the prognosis of patients, but also increases the mortality rate after hospitalization and dischar...

Claims

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Application Information

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IPC IPC(8): G16H20/40G16H50/20G16H50/30G16H50/50
CPCG16H20/40G16H50/20G16H50/30G16H50/50
Inventor 吴晓云臧旺福周健金相兰
Owner NANJING MEDICAL UNIV
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