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A kind of skin restoration preparation and its preparation method and application

A preparation and skin technology, which is applied in the field of skin repair preparations and its preparation, can solve the problems of cumbersome preparation and limited clinical use, and achieve the effects of simple process flow, excellent biodegradability, and rapid wound repair ability

Active Publication Date: 2022-05-24
北京方诣生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention solves the problems in the prior art that the preparation is cumbersome and the medicines in the prescription limit its clinical use

Method used

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  • A kind of skin restoration preparation and its preparation method and application
  • A kind of skin restoration preparation and its preparation method and application
  • A kind of skin restoration preparation and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] (1) Weigh the molecular weight of 200KDa medical grade prolanose 50g, succinate anhydride 200g, 4-dimethylaminopyridine 10g dissolved in 2500mL dimethyl sulfoxide, reaction at 50 °C for 24h, the reaction solution for dialysis for 48h, dialysate at -60 °C prefreezing for 12h, the resulting prefreezing product at -60 °C, 0.1Pa under vacuum conditions freeze-dried for 24h, that is, succinyl prolanose;

[0073] (2) Weighing step (1) preparation of succinyl prorulanose 50g, 4-dimethylaminopyridine 10g, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 25g dissolved in 3000mL dimethyl sulfoxide, magnetic stirring at room temperature to give succinyl prolan sugar solution;

[0074](3) Weigh the molecular weight of 5KDa medical grade hyaluronic acid 50g dissolved in 2500mL dimethyl sulfoxide, stir evenly, to obtain hyaluronic acid solution;

[0075] (4) The hyaluronic acid solution prepared in step (3) of 2500 mL was added to the succinyl proram sugar solution prepared at...

Embodiment 2

[0080] (1) Weigh the molecular weight of 50KDa medical grade chitosan 50g, succinate anhydride 150g dispersed in methanol solution, 50 °C reaction 24h, the reaction solution for dialysis for 48h, dialysate at -60 °C prefreezing for 12h, the obtained prefreezed product at -60 °C, 0.1Pa under vacuum conditions freeze-dried for 24h to obtain succinate chitosan;

[0081] (2) Weighing step (1) preparation of succinyl chitosan 50g, 4-dimethylaminopyridine 10g, 1- (3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 25g dissolved in 2500mL dimethyl sulfoxide, magnetic stirring at room temperature to give succuctoyl chitosan solution;

[0082] (3) Weigh 25g of medical grade prolanose with a molecular weight of 200KDa dissolved in 200mL dimethyl sulfoxide, stir evenly to obtain a prelanose solution;

[0083](4) Weigh 5KDa medical grade hyaluronic acid 25g dissolved in 200mL dimethyl sulfoxide, stir evenly to obtain hyaluronic acid solution;

[0084] (5) The propellant sugar solution p...

Embodiment 3

[0086] (1) Weigh the molecular weight of 200KDa medical grade prolanose 50g, succinate anhydride 50g, 4-dimethylaminopyridine 5g dissolved in 2500mL dimethyl sulfoxide, reaction at 60 °C for 36h, the reaction liquid for dialysis for 48h, dialysate at -60 °C prefreezing for 12h, the obtained prefreezed product at -60 °C, 0.1Pa vacuum conditions freeze-dried for 24h, that is, succinyl proclamose;

[0087] (2) Weighing step (1) preparation of succinyl prolanose 50g, 4-dimethylaminopyridine 5g, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 50g dissolved in 3000mL dimethyl sulfoxide, magnetic stirring at room temperature to give succinyl prolan sugar solution;

[0088] (3) Weigh 50g of medical grade hyaluronic acid with a molecular weight of 5KDa and dissolve it in 2000mL dimethyl sulfoxide, stir evenly to obtain hyaluronic acid solution;

[0089] (4) The hyaluronic acid solution prepared at step (3) of 2000 mL was added dropwise to the succyl prolanose solution prepared ...

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Abstract

The invention discloses a preparation for repairing skin surface wounds and its preparation method and application. It uses natural polymer polysaccharides such as chitosan, hyaluronic acid and pullulan as raw materials, uses succinic anhydride as a connecting arm, and uses 4-2 Aminopyridine is a catalyst, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a dehydrating agent, the product is dialyzed to remove the catalyst and dehydrating agent, and freeze-dried to obtain hyaluronic acid-based puru Lanose, physically mixed with chitosan to form a film to obtain a skin surface wound repair film preparation; or use succinylated chitosan to link hyaluronic acid and pullulan to obtain chemically grafted chitosan-hyaluronic acid ‑Surface wound repair film preparation of pullulan polymer material. The skin surface wound repair preparation of the present invention has good biocompatibility, can effectively stop bleeding, antibacterial, absorb wound area fluid, keep wound surface moist, promote epithelial cell growth, accelerate wound surface healing, and its preparation raw material source is extensive, and cost is low, The preparation conditions are mild, the production route is simple, and the product quality is easy to control.

Description

Technical field [0001] The present invention relates to a field of pharmaceutical materials, particularly to a skin repair formulation and preparation method and application thereof. Background [0002] The skin is an essential interface between the body and the environment, and the key factors in death from skin trauma are mainly uncontrolled bleeding and infection of wounds. Conventional wound dressings in clinical applications are natural or synthetic bandages, such as cotton balls, gauze, etc., which have poor hemostasis effect, can not prevent infection and can not promote wound healing, and even adhere to the dry wound surface to cause secondary trauma. Many clinical hemostatic preparations use hemostatic active proteins such as fibrin, collagen and thrombin, and although their hemostatic effect is significant, they are difficult to store and use outside the hospital. For wound infections, the main cause is bacterial infections caused by Staphylococcus aureus, E. coli, etc....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/44A61L15/46
Inventor 杨文智付国亮李凯悦李海鹰
Owner 北京方诣生物医药有限公司
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