Self-healing medical gel

A self-healing, gel technology, applied in the field of medicine, can solve the problems of increasing the workload of medical workers, large wound infection, etc., and achieve the effect of ensuring integrity, ensuring flexibility and maintaining mechanical strength

Inactive Publication Date: 2019-05-17
QINGDAO ZHONGTENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is widely used in clinical fields such as burns, scalds and chronic wounds, but it is necessary to remove barriers such as dressings on the wound during operation. Long-term exposure of the wound and repeated operations have a high probability of infection, and it also greatly increases the work of medical workers. quantity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: 5% hyaluronan solution was reacted with dopamine to obtain dopamine-modified hyaluronan with a dopamine content of 15%. The purified product was formulated into a 5% aqueous solution and mixed with genipin and ferric chloride And waterproof lamp bead particle type LED light strip blended for a period of time, obtained from healing medical gel. The addition ratio of genipin to the system is 0.5%, and the addition ratio of ferric chloride is 0.2%.

Embodiment 2

[0018] Embodiment 2: 10% polylysine solution reacts with dopamine to obtain dopamine-modified polylysine, the content of dopamine is 25%, the product after purification is formulated into 10% aqueous solution, and with sebacic acid disuccinimide Ester and Ferric Chloride and Waterproof Lamp Beads Granular LED Strips are blended for a period of time to obtain healing medical gel. The addition ratio of disuccinimide sebacate to the system is 1.2%, and the addition ratio of ferric chloride is 0.5%.

Embodiment 3

[0019] Example 3: Chitosan and collagen are blended and dissolved to make an aqueous solution and react with dopamine to obtain a dopamine-modified proteoglycan mixed solution, wherein the content of chitosan is 2%, the content of collagen is 9%, and the content of dopamine is 12%. , the purified product is formulated into a 10% aqueous solution, and blended with four-arm polyethylene glycol succinimide glutarate, ferric chloride and a waterproof semiconductor solid-state cold light source LED sheet for a period of time, obtained from Healing Medical gel. The addition ratio of four-arm polyethylene glycol succinimide glutarate in the system is 0.8%, and the addition ratio of ferric chloride is 0.5%.

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PUM

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Abstract

The invention discloses a self-healing medical gel, belonging to a medical material. The self-healing medical gel is a medical gel that has a double crosslinked and double-network structure and has self-healing capability and is formed by blending a polysaccharide or protein partially modified by dopamine, a crosslinking agent and iron ions. A modified material is high in strength and good in biocompatibility. A red and blue light generator is distributed in the gel to increase collagen fibers of the wound, thereby promoting wound healing and avoiding the contamination risk caused by removal of a dressing during phototherapy, labor intensity of medical workers is reduced, and the self-healing medical gel has a strong application prospect in the field of medical rescue.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a self-healing medical gel. Background technique [0002] Gel is a polymer that uses water as the dispersion medium to form an internal network of polymers through physical or chemical crosslinking. In medicine, hydrogel is a class of materials with great potential for development. It has outstanding properties that some traditional materials do not have, making it more and more widely involved in the field of biomedical high-tech fields. Hydrogel has a three-dimensional network structure, can absorb a large amount of water to swell in water, and continue to maintain its original structure without being dissolved after swelling. Hydrogel is similar to living tissue materials, and its surface adhesion to proteins and cells is very weak. When in contact with blood, body fluids and human tissues, it shows good biocompatibility. It does not affect the metabolic process of living or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/06A61K9/06A61K47/36A61K47/42A61P17/02
Inventor 李洪波金海明
Owner QINGDAO ZHONGTENG BIOTECH
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