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Application of terminal effector T cell subsets in the preparation of kits for assisting in evaluating the severity of aplastic anemia

An aplastic and cell subset technology, applied in the field of biomedicine, can solve problems such as the characteristic changes of terminal effector T cells in patients with AA that have not yet been seen, and achieve the effect of broad application prospects.

Active Publication Date: 2022-04-26
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, there are no relevant reports on the characteristic changes of terminal effector T cells in AA patients

Method used

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  • Application of terminal effector T cell subsets in the preparation of kits for assisting in evaluating the severity of aplastic anemia
  • Application of terminal effector T cell subsets in the preparation of kits for assisting in evaluating the severity of aplastic anemia
  • Application of terminal effector T cell subsets in the preparation of kits for assisting in evaluating the severity of aplastic anemia

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Experimental program
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Embodiment 1

[0062] (1) Blood was collected under the premise of signing informed consent with AA patients, and all samples were taken from intravenous EDTA anticoagulation on an empty stomach in the morning. A total of 16 peripheral blood samples were collected from patients with AA, including 8 cases of SAA and 8 cases of NSAA. At the same time, 20 samples of healthy people were collected, and this part of the research protocol has been approved by the ethics committee of the unit. At the same time, clinical data such as hemoglobin (HB), platelets (PLT) and absolute neutrophil count (ANC) of AA patients were collected (as shown in Table 1).

[0063] Table 1 Clinical data of AA patients

[0064] Numbering gender age diagnosis HB(g / L) PLT (10 9 / L)

ANC (10 9 / L)

A1 M 34 SAA 59 39 1.16 A2 M 25 SAA 68 20 0.53 A3 M 28 SAA 52 20 2.15 A4 M 28 SAA 87 22 0.4 A5 M 31 SAA 71 34 0.54 A6 F 20 SAA 68 6 0.1...

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Abstract

The invention discloses the application of terminal effector T cell subsets in the preparation of a kit for assisting in evaluating the severity of aplastic anemia. The inventors of the present invention found for the first time that CD8 in the peripheral blood of patients with AA + CD45RO ‑ CD27 ‑ The proportion of T cells was significantly decreased in AA patients, especially in SAA. CD8 in peripheral blood of patients with SAA + CD45RO ‑ CD27 ‑ The proportion of T cells is significantly lower than the characteristic changes of NSAA patients, which can be used as one of the laboratory immune-related detection indicators to assist in evaluating the severity of AA patients. reference materials.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of a terminal effector T cell subset in the preparation of a kit for assisting in evaluating the degree of aplastic anemia. Background technique [0002] Aplastic anemia (AA) is a bone marrow hematopoietic failure syndrome characterized by decreased bone marrow hematopoietic cell proliferation and pancytopenia. Anemia, bleeding and infection are the main clinical manifestations of AA. The annual incidence of AA in my country is higher than that in Europe and America. The current clinical diagnostic criteria for AA are mainly based on the routine examination of peripheral blood, multi-site bone marrow puncture smear analysis, bone marrow biopsy, and the exclusion of congenital and pancytopenia and other diseases of bone marrow hypoplasia. The evaluation of AA with different degrees of disease is mainly based on the degree of bone marrow cell proliferation an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/577G01N33/533G01N33/58G01N15/14
Inventor 李萡张玉平李扬秋赵素文黄桂璇王顺清肖彦恺周铭黎宇苗
Owner JINAN UNIVERSITY
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