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Application of a kind of buquinal in preparation of medicine for preventing foot-and-mouth disease virus infection

A foot-and-mouth disease virus and drug technology, applied in antiviral agents, active ingredients of heterocyclic compounds, etc., can solve the problems of strong infectivity of foot-and-mouth disease, many susceptible people, and difficulties in the prevention and control of foot-and-mouth disease

Active Publication Date: 2021-07-23
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disease has the characteristics of rapid and long-distance transmission, many susceptible people, and strong infectivity of foot-and-mouth disease, which brings certain difficulties to the prevention and control of foot-and-mouth disease

Method used

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  • Application of a kind of buquinal in preparation of medicine for preventing foot-and-mouth disease virus infection
  • Application of a kind of buquinal in preparation of medicine for preventing foot-and-mouth disease virus infection
  • Application of a kind of buquinal in preparation of medicine for preventing foot-and-mouth disease virus infection

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0026] 1. Experimental materials

[0027] 1.1 Cells, Animals, Viruses and Drugs

[0028] IBRS-2 cells were preserved by our research group; 3-day-old suckling mice were purchased from the Experimental Animal Farm of Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. FMDV (O / MY98 / BY / 2010 and A / GDMM / CHA / 2013) was preserved and provided by the National Foot-and-Mouth Disease Reference Laboratory; BQR was purchased from MCE Company and prepared with DMSO.

[0029] 1.2 Reagents

[0030] DMEM, fetal bovine serum FBS, and trypsin medium were purchased from Gibco; MTS detection kit was purchased from Abcam; TRIzol was purchased from Invitrogen; SYBR Premix Ex Taq Ⅱ The kits were purchased from Bao Bioengineering (Dalian) Co., Ltd.; RIPA lysate, BCA method protein quantification kit, SDS-PAGE gel preparation kit, ECL were purchased from Biyuntian Company; BSA and PVDF membranes were purchased from BioRad Company; Tween-20 and Tween-80 were purchased fro...

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Abstract

The invention relates to the application of buquinal in the preparation of medicines for preventing foot-and-mouth disease virus infection, and belongs to the technical field of veterinary medicines. The application of the invention can provide a class of highly efficient, safe and quality-controllable anti-foot-and-mouth disease virus medicine for further controlling the spread of foot-and-mouth disease.

Description

technical field [0001] The invention relates to the technical field of veterinary medicines, in particular to the application of buquinal in the preparation of medicines for preventing foot-and-mouth disease virus infection. Background technique [0002] Foot-and-mouth disease is an acute, febrile, and highly contagious animal disease caused by foot-and-mouth disease virus. The characteristic symptoms of affected animals are blisters on the mouth, nose, hooves, and nipples of female animals, or ulcers or plaques formed after blisters are damaged. It shows drooling, wrestling and lying on the ground, which leads to a sharp decline in productivity and huge economic losses. my country has listed foot-and-mouth disease as one of the priority diseases, which fully demonstrates the degree of attention that countries have paid to the disease. The disease has the characteristics of rapid and long-distance transmission, a large number of susceptible people, and strong infectivity of f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/47A61P31/14
Inventor 常惠芸李世芳龚美娇邵军军赵付荣常艳燕张永光
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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