A preparation method of fumagillin amino alcohol

The technology of fumagillin amino alcohol and fumagillin is applied in the preparation field of fumagillin amino alcohol, which can solve the problem that fish endanger fish health and freshwater aquaculture, and affect beekeeping and agricultural production activities. Influence and other problems, to achieve the effect of reducing separation and purification steps, low toxicity and high synthesis efficiency
CN109867640AInactive Publication Date: 2019-06-11INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
3 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
Publication Date
2019-06-11
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method of fumagillin amino alcohol shown as a formula I in the specification. The method comprises the following steps: (1) reducing amino acid shown in a formulaII to obtain a compound shown in a formula III; and (2) carrying out an ammonium salt synthesis reaction on fumagillin and the compound shown in the formula III to obtain fumagillin amino alcohol. The preparation method is short in reaction route and high in synthesis efficiency, the separation and purification steps are reduced, and mass production can be achieved. Meanwhile, the synthesized fumagillin amino alcohol is low in toxicity, can be dissolved and degraded in nature and is good in water solubility.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of organic synthesis, and in particular relates to a preparation method of fumagillin amino alcohol. Background technique

[0002] Fumagillin is an antibiotic drug mainly used to treat microsporidiosis. Microsporidiosis mainly parasitizes in the epithelial cells of the digestive tract of insects and the skin and muscles of fish, and is also found in annelids and some other invertebrates. The impact of crops on microsporidiosis cannot be ignored. For example, the harmful effect of microsporidiosis on bees not only seriously affects beekeeping, but also has an impact on crop pollination and even the entire agricultural production activities; at the same time, its impact on fish has seriously endangered the health of fish and freshwater aquaculture . Judging from the effect of preventing and treating microsporidiosis abroad, fumagillins are the best choice to replace antifungal drugs such as metronidazole. In recent ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More