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Preparation and application of sea cucumber monomer saponins

A sea cucumber and saponin technology, applied in the field of sea cucumber extracts, can solve the problems of few researches on the preparation method of sea cucumber monomer saponins, and achieve the effects of remarkable medicinal effect, strong controllability and stable quality.

Inactive Publication Date: 2019-06-14
陕西卓力时代人力资源有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Existing literature mainly focuses on the extraction process and content determination of sea cucumber polysaccharides in sea cucumbers, and there are few studies on the preparation methods of sea cucumber monomeric saponins

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 500g of sea cucumber eviscerated, dried and extracted three times with 65% n-butanol, the dosage is 2000ml, each time for 1 week, the three extracts are filtered, combined and concentrated to no alcohol, adsorbed by macroporous adsorption resin, washed with water until Colorless, first eluted with 30% n-butanol, then 60% n-butanol, concentrated 60% n-butanol eluate, and dried to obtain 105 g, with aglycone content of 18%.

Embodiment 2

[0025] 500g dried whole sea cucumber eviscerated, extracted three times with 75% n-butanol, the dosage is 2000ml each time, each time for 1 week, filtered and combined the filtrate, the filtrate was concentrated and applied to the column, washed with water until colorless, first used 30% N-butanol was eluted, then eluted with 60% n-butanol, concentrated 60% n-butanol eluate, and dried to obtain 86 g, and the amount of aglycone was 47%.

Embodiment 3

[0027] 500g dried whole sea cucumber eviscerated, and extracted three times with 85% n-butanol. The dosage is 2000ml each, and each time is left standing for 1 week. Filter and combine the filtrate. N-butanol was eluted, then eluted with 60% n-butanol, concentrated 60% n-butanol eluate, and dried to obtain 61 g, and the amount of aglycone was 62%.

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Abstract

The invention belongs to the medical technical field, and in particular, relates to sea cucumber monomer saponins extracted from animal sea cucumber bodies, wherein based on the weight percentage of the sea cucumber monomer saponins, ananaside A accounts for 18%-60% of the extract. The invention also provides a preparation method and an application of the sea cucumber monomer saponins. The sea cucumber extract has low cost, strong controllability and stable quality.

Description

technical field [0001] The invention relates to a sea cucumber extract, in particular to monomer saponins extracted from natural medicinal material sea cucumber (Thelenota ananas Jaeger) as raw material, a preparation method and application of the extract, and belongs to the field of medicine. Background technique [0002] Sea cucumbers, belonging to the class of Holothuroidea, are marine echinoderms that live in the sea to 8,000 meters, with a history of more than 600 million years. Sea cucumbers feed on seabed algae and plankton. Sea cucumbers are covered with thorns all over the body and are widely distributed in the oceans of the world. There are many kinds of sea cucumbers along the coast of the South China Sea, and there are more than 20 kinds of sea cucumbers that can be eaten. [0003] The molecular structure of sea cucumber saponins is very complex. The substitution positions of carbon-carbon double bonds, hydroxyl groups, ketone groups and other functional groups ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/616A61P35/00
Inventor 程淑清牛清玲
Owner 陕西卓力时代人力资源有限公司
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