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Inclusion complex of modified chitosan carrier and drug and preparation method thereof

A technology of chitosan and clathrate is applied in the clathrate of modified chitosan carrier and medicine and its preparation field, and achieves good application prospect and low toxicity effect.

Active Publication Date: 2022-03-25
广东康嘉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no drug carrier containing lactose or galactose and bile acid

Method used

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  • Inclusion complex of modified chitosan carrier and drug and preparation method thereof
  • Inclusion complex of modified chitosan carrier and drug and preparation method thereof
  • Inclusion complex of modified chitosan carrier and drug and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0033] The raw materials in the examples are all in parts by weight.

[0034] Step 1: Preparation of Modified Chitosan

[0035] At normal temperature, 1 part of lactose and 10 parts of liver acetate were reacted in pyridine for 24 hours; 1 part of mercaptopropionic acid and 10 parts of boron trifluoride ether were added to react in dichloromethane for 8 hours; methanol was added, pH The value was adjusted to 9, and lactosyl mercaptopropionic acid was obtained after 3 hours of reaction. 1 part of lactosylmercaptopropionic acid and 1.2 parts of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI), 1 part of N-hydroxysuccinimide ( NHS), stir in dimethyl sulfoxide for 1 hour, add chitosan solution adjusted to pH 4 in advance, stir for 24 hours, dialyze with ultrapure water in a 13000 dialysis bag for 3 days, freeze-dry Obtain lactose-modified chitosan for subsequent use;

[0036] At room temperature, 1 part of galactose and 14 parts of liver acetate were reacted i...

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Abstract

The invention discloses an inclusion compound of modified chitosan carrier and medicine and a preparation method thereof. The inclusion compound of modified chitosan carrier and medicine is modified chitosan, icariin and paclitaxel , a kind of clathrate in Sorafenib; The modified chitosan is lactose modified chitosan, galactose modified chitosan, lactose cholic acid modified chitosan, galactose cholic acid A kind of in modified chitosan; The method for preparing the clathrate of modified chitosan carrier and medicine comprises getting 5~20 parts of one of icariin, paclitaxel, sorafenib and adding to 1~ 5 parts of methanol to make a drug solution for later use; take 20-40 parts of the modified chitosan and add it to 10-20 parts of water to make a main body solution for later use; add the drug solution dropwise to the main body solution , ultrasonic treatment for 5-10 minutes after the dropwise addition, and then dialysis with a dialysis membrane for 12-18 hours, centrifugation of the solution after dialysis, taking out the supernatant obtained after centrifugation, and freeze-drying to obtain modified chitosan Inclusion complexes with drugs.

Description

technical field [0001] The invention relates to the field of polymer synthesis, in particular to an inclusion compound of a modified chitosan carrier and a drug and a preparation method thereof. Background technique [0002] Lactose, cholic acid, and galactose all have good liver targeting properties. After they are linked with polymer compounds, such as chitosan, they can be used as drug carriers. In the prior art, lactose is oxidized and ring-opened to produce galactose. Galactose has a certain liver targeting property, and the functional group on galactonic acid is used to link it to other macromolecules. In the prior art, there is no pharmaceutical carrier containing lactose or galactose and bile acid. SUMMARY OF THE INVENTION [0003] The technical problem to be solved by the present invention is: to provide an inclusion compound of a modified chitosan carrier and a drug, the structure of which contains lactose or galactose and cholic acid; to provide the inclusion c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/36A61K31/7048A61K31/337A61K31/44C08B37/08
Inventor 丁毅力庞裕昌李紫元张建州刘真毓詹志浩张宇煊郑向东王丙云
Owner 广东康嘉生物科技有限公司
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