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A biomedical silicone rubber with antibacterial properties

A biomedical and silicone rubber technology, applied in the field of biomedical antibacterial, can solve the problems of nano-silver slow release, and achieve the effect of low cytotoxicity, low cytotoxicity and wide sources

Active Publication Date: 2021-06-29
山西大医院 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, graphene-loaded nano-silver still faces a problem - the slow release of nano-silver cannot be achieved, thereby prolonging the service life of antibacterial agents

Method used

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  • A biomedical silicone rubber with antibacterial properties
  • A biomedical silicone rubber with antibacterial properties
  • A biomedical silicone rubber with antibacterial properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prepare graphene oxide according to the Hummers method, dry it to obtain graphite oxide, and reduce the obtained graphite oxide to graphene by high-temperature calcination in an intelligent tube furnace; place the graphene solution under alkaline conditions in 100ml of polytetrafluoroethylene In the lining, hydrothermal reaction was carried out at 180°C for 12 hours, cooled at room temperature, filtered, and dialyzed to obtain graphene quantum dots (GQDs).

[0029] Add 60ml of ethanol to the beaker, add 10mg of the prepared nano-silver particles, ultrasonically stir for 1h, add 1ml of silane coupling agent, and ultrasonically for 1h to obtain Ag-silane coupling agent mixed solution, add 20ml of absolute ethanol to the beaker, add 1 mg of graphene quantum dots, ultrasonication for 30 minutes, and magnetic stirring for 30 minutes at room temperature to obtain a dispersion of graphene quantum dots. Pour the dispersion of graphene quantum dots into the purified Ag-silane co...

Embodiment 2

[0032] Add 70ml of ethanol to the beaker, add 15mg of the prepared silver nanoparticles, sonicate for 1h, add 1ml of silane coupling agent, and sonicate for 1h to obtain the Ag-silane coupling agent mixture; add 20ml of absolute ethanol to the beaker, add 1mg Graphene quantum dots, ultrasonication for 30 minutes, and magnetic stirring for 30 minutes at room temperature to obtain a dispersion of graphene quantum dots. Pour the dispersion of graphene quantum dots into the purified Ag-silane coupling agent solution, ultrasonically disperse for 1 h, magnetically stir for 1 h, and dry in vacuum at 60° C. to obtain graphene quantum dot-coated silver nanoparticles.

[0033] Add 50ml of liquid silicone rubber into a beaker and stir for 10min; take 1g of graphene quantum dot-coated nano-silver antibacterial agent and place it in a 50ml beaker, add 10 parts of solvent, ultrasonicate for 30min, then add it to the liquid silicone rubber and stir for 10min; Add 1.5ml of curing agent to the...

Embodiment 3

[0035] Add 80ml of ethanol to the beaker, add 20mg of the prepared silver nanoparticles, sonicate for 1h, add 1ml of silane coupling agent, and sonicate for 1h to obtain the Ag-silane coupling agent mixture; add 20ml of absolute ethanol to the beaker, add 1mg Graphene quantum dots, ultrasonication for 30 minutes, and magnetic stirring for 30 minutes at room temperature to obtain a dispersion of graphene quantum dots. Pour the dispersion of graphene quantum dots into the purified Ag-silane coupling agent solution, ultrasonically disperse for 1 h, magnetically stir for 1 h, and dry in vacuum at 60° C. to obtain graphene quantum dot-coated silver nanoparticles.

[0036] Add 50ml of liquid silicone rubber into a beaker and stir for 10min; take 1g of graphene quantum dot-coated nano-silver antibacterial agent and place it in a 50ml beaker, add 10 parts of solvent, ultrasonicate for 30min, then add it to the liquid silicone rubber and stir for 10min; Add 2ml of curing agent to the m...

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Abstract

The invention relates to the field of biomedical antibacterial. A kind of biomedical silicone rubber with antibacterial property, by weight, 50-80 parts of liquid silicone rubber is added in the beaker, stirred for 10min; 5 parts of graphene quantum dot-coated nano-silver antibacterial agents are placed in the 50ml beaker, and Add 10 parts of solvent, ultrasonic for 30min; add the graphene quantum dot coated nano-silver antibacterial agent solution prepared in step 2 to the liquid silicone rubber prepared in step 1, and stir for 10min; add 1-2 parts to the solution prepared in step 3 Curing agent, stirred for 5 minutes; in a flat vulcanizer, press vulcanized at room temperature to obtain biomedical silicone rubber with good antibacterial properties. The modified silicone rubber not only continues the advantages of traditional silicone rubber biocompatibility, but also improves the antibacterial properties of rubber and prolongs the use time of silicone rubber in biomedicine.

Description

technical field [0001] The invention relates to the field of biomedical antibacterial. Background technique [0002] With the development of society and the acceleration of human social life activities, bacteria are also spreading and spreading at an unprecedented speed. In our lives, bacteria exist everywhere, and the removal of bacteria has become particularly important. Various bactericides, sterilizers, and disinfectants are applied. Traditional fungicides can be divided into organic antibacterial agents, inorganic antibacterial agents, and natural antibacterial agents. Although there are many kinds of organic antibacterial agents, they have poor thermal stability and thermal decomposition products are more harmful to the environment; natural antibacterial agents have a wide range of sources, but purification and processing are difficult, and the thermal decomposition temperature is low, which cannot meet the high processing temperature; the stability of inorganic antib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L83/04C08K9/10C08K3/04C08K3/08
Inventor 张利王洁牛梅于世平杨永珍张雁钢
Owner 山西大医院
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