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Preparation method of chondroitin sulfate sustained-release granule

A technology of chondroitin sulfate and preparation, which is applied in the field of medicine and can solve the problems of short half-life and unstable activity

Inactive Publication Date: 2019-07-02
青岛华迈士药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Compared with other fibrinases, urokinase has the advantages of no pyrogen, no antigenicity, less toxic and side effects, high specificity and definite curative effect, but its half-life in the human body is short and its activity is unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] 1. Take aconite (made) and crush it, add 1 / 2 times the weight of the medicinal material in purified water adjusted to pH 3-4 with hydrochloric acid, soak for 12 hours, add 2 times the weight of the medicinal material and adjust the pH to 3-4 with hydrochloric acid Decoct with purified water, boil for half an hour, filter and retain the filtrate, take the filter residue and add 2 times the weight of the medicinal material and use hydrochloric acid to adjust the pH to 3-4 for decoction, boil for half an hour, filter, combine the two filtrates and concentrate , extracted twice with 75% ethanol, filtered, combined filtrates, and concentrated under reduced pressure until the weight of the paste was about 10% of the raw material; another Radix Paeoniae Alba was crushed, moistened with 70% ethanol, left to stand overnight, and the medicinal material 2 Double the weight of 70% ethanol for reflux extraction for 2-3 hours, filter, take the filter residue and add 1 times the weight...

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PUM

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Abstract

The present invention belongs to the technical field of medicines and particularly relates to a compound chondroitin sulfate preparation and a preparation method thereof. The provided compound chondroitin sulfate preparation comprises the following components in weight: chondroitin sulfate, (prepared) radix aconiti carmichaeli, radix paeoniae alba, a licorice extractum, starch and dextrin. The compound chondroitin sulfate preparation obtained by using the preparation method of the compound chondroitin sulfate easily disintegrates after being taken, is liable to be absorbed, better in medicineeffects and not complicated in processes, saves costs to a certain extent, and is suitable for large-scale production applications.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a compound chondroitin sulfate preparation and a preparation method thereof. Background technique [0002] Urokinase is a fibrinogen lytic enzyme extracted from adult male urine that can activate fibrinogen and generate soluble fibrinogen. It is widely used clinically in the treatment of fresh thrombotic occlusive disease, pulmonary embolism, Acute cerebral thrombosis, cerebral vascular embolism, and central retinal vein thrombosis. [0003] Compared with other fibrinases, urokinase has the advantages of no pyrogen, no antigenicity, less toxic and side effects, high specificity and definite curative effect, but its half-life in the human body is short and its activity is unstable. Chemical modification of the side chain group of urokinase, especially through covalent linkage with some active molecular groups, can enhance its conformational stability, acid and alkali resistance,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/20A61K47/36A61K31/737
CPCA61K9/2059A61K31/737A61K36/484A61K36/65A61K36/71A61K36/714A61K2300/00
Inventor 刘乃山隋丰
Owner 青岛华迈士药业有限公司