The invention relates to a bio-capsule for treating secondary hyperlipemia and a preparation method. Raw materials of active ingredients of the bio-capsule include commom banana pericarp, oenanthe javanica, radix clerodendri philippini, lotus petiole, biondia henryi, henbit, radix dipsaci, common seseli herb, crepis rigescens, crataegus root, all grass of anderson cirrhopetalum, tilia, twig and leaf of java bishopwood, lettuce seeds, chondroitin sulfate a, pantethine and lifibrate. The bio-capsule for treating the secondary hyperlipemia has the advantages that traditional Chinese medicines with efficacy of clearing heat, detoxifying, dispersing blood stasis, dredging collateral, removing food retention, harmonizing stomach, invigorating spleen, promoting digestion, nourishing liver and kidney, strengthening muscles and bones, conditioning blood vessels and the like are combined reasonably and used to cooperate with western medicine ingredients, by the aid of combination of the medicines, metabolic waste in blood can be cleared, the blood can be purified, lipid metabolism of a human body can be improved, decomposition course of lipid can be accelerated, fat accumulation in the human body can be decreased, blood lipid level can be lowered, complications like cardiovascular and cerebrovascular diseases and the like can be prevented, and proved by clinical verification, the bio-capsule is free of toxic, side or untoward effect and is applicable to wide popularization and application.