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Preparation technology of chondroitin sulfate A nano selenium freeze-dried powder injection

A chondroitin sulfate and freeze-dried powder injection technology, which is applied in the field of biomedical preparation preparation, can solve the problems of inability to effectively overcome the closeness of the effective dose and the toxic dose, low bioavailability efficiency, low absorption rate, poor stability, and limited wide application, etc. Achieve optimal bioavailability and activity, overcome allergic reactions, and achieve optimal biocompatibility

Inactive Publication Date: 2019-11-08
XI AN JIAOTONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing selenium supplementation preparations of dosage forms such as sodium selenite tablets and injections cannot effectively overcome the shortcomings of effective dose and poisoning dose, low bioavailability, low absorption rate, poor stability, etc., thus greatly limiting its use. Wider application

Method used

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  • Preparation technology of chondroitin sulfate A nano selenium freeze-dried powder injection
  • Preparation technology of chondroitin sulfate A nano selenium freeze-dried powder injection
  • Preparation technology of chondroitin sulfate A nano selenium freeze-dried powder injection

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Embodiment Construction

[0032] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0033] It should be noted that the terms "comprising" and "having" and any variations thereof are intended to cover a non-exclusive inclusion, for example, a process, method, system, product or device comprising a series of steps or units is not necessarily limited to expressly instead of those steps or elements listed, may include ...

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Abstract

The invention discloses a preparation technology of a chondroitin sulfate A nano selenium freeze-dried powder injection, and belongs to the technical field of preparation of biomedical preparations. According to the adopted scheme, chondroitin sulfate A serves as a carrier to carry nano selenium particles obtained by reduction of sodium selenite and L-ascorbic acid for reaction in water so as to generate chondroitin sulfate A nano selenium liquid; unreacted substances in the prepared chondroitin sulfate A nano selenium liquid are removed through a molecular sieve, then filtering is conducted to remove bacteria and impurities, after physical characteristics are checked, the chondroitin sulfate A nano selenium liquid is split-charged into penicillin bottles, half plug-compressing is conducted, then vacuum freeze-drying treatment is conducted, plug-compressing is conducted for compressing aluminum caps, and the chondroitin sulfate A nano selenium freeze-dried powder injection is prepared,and stored in a frozen mode for standby application. According to the preparation technology, the process is simple, the quality is stable and controllable, physicochemical properties of prepared products are stable, and the preparation technology is suitable for industrial scale production.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical preparations, and relates to a preparation process of chondroitin sulfate A nano-selenium freeze-dried powder injection. Background technique [0002] Chondroitin sulfate (Chondroitin sulfate, CS) is a proteoglycan widely distributed in the extracellular matrix of cartilage. It is one of the main components of normal cartilage matrix and plays an important role in the maintenance of normal joint function and biomechanical stability. In addition, CS has certain antioxidant and anti-fibrosis activities, and plays a positive role in the repair of articular cartilage damage. As a good joint supplement, CS is often used in the prevention and treatment of various bone and joint diseases. Currently, CS widely used is mostly artificially synthesized preparations with relatively low cost, but its potential negative effects such as allergic reactions, body rejection reactions, and immune ...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/737A61K33/04A61K47/22A61P3/02A61P19/02A61P29/00
CPCA61K9/0019A61K9/19A61K31/737A61K33/04A61K47/22A61P3/02A61P19/02A61P29/00A61K2300/00
Inventor 韩晶雷剑王丽云冉艳郭雄
Owner XI AN JIAOTONG UNIV
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