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Compound glucosamine sulfate dispersible tablet formulation and its preparation method

A technology of glucosamine sulfate and dispersible tablets, which is applied in the field of medicine and can solve problems such as affecting the full effect of the drug and slow onset of action

Active Publication Date: 2006-04-26
GUANGZHOU YIPINHONG PHARMA +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, the compound drugs using glucosamine and chondroitin sulfate are mainly in the form of capsules and tablets.

Method used

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  • Compound glucosamine sulfate dispersible tablet formulation and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The formula of dispersible tablet is;

[0048] Glucosamine Sulfate Sodium Chloride Double Salt 314g

[0049] Chondroitin Sulfate 200g

[0050] Starch 50g

[0051] 100g microcrystalline cellulose

[0052] Crospovidone (internal type) 350g

[0053] Crospovidone (external type) 350g

[0054] Magnesium Stearate 20g

[0055] 16 grams of absolute ethanol

[0056] A total of 1000 tablets were made, each weighing 1.4 grams.

[0057] Glucosamine sulfate in 314 grams of glucosamine sulfate sodium chloride double salt is 250 grams.

[0058] Preparation steps: each raw material is passed through an 80-mesh sieve and pulverized; glucosamine sulfate sodium chloride double salt, chondroitin sulfate, starch, microcrystalline cellulose and crospovidone (internal addition type) are placed in a container and fully stirred and mixed Mix well, then add absolute ethanol solution for wetting, pass through 20 mesh to granulate, and dry at 45°C for 75 minutes; add the remaining crospovi...

Embodiment 2

[0060] The formula of dispersible tablet is;

[0061] Glucosamine Sulfate Sodium Chloride Double Salt 314g

[0062] Chondroitin Sulfate 196g

[0063] Starch 55g

[0064] Microcrystalline Cellulose 105g

[0065] Crospovidone (internal type) 340g

[0066] Crospovidone (external type) 350g

[0067] Magnesium Stearate 22g

[0068] 18 grams of absolute ethanol

[0069] A total of 1000 tablets were made, each weighing 1.4 grams.

[0070] Preparation steps: each raw material is passed through an 80-mesh sieve and pulverized; glucosamine sulfate sodium chloride double salt, chondroitin sulfate, starch, microcrystalline cellulose and crospovidone (internal addition type) are placed in a container and fully stirred and mixed Mix well, then add absolute ethanol solution for wetting, pass through 24 mesh to granulate, and dry at 40°C for 90 minutes; add the remaining crospovidone (additional type) and magnesium stearate, and then granulate at 24 mesh; mix well , Determining the co...

Embodiment 3

[0072] The formula of dispersible tablet is;

[0073] Glucosamine Sulfate Sodium Chloride Double Salt 314g

[0074] Chondroitin Sulfate 206g

[0075] Starch 50g

[0076] Microcrystalline Cellulose 94g

[0077] Crospovidone (internal type) 345g

[0078] Crospovidone (external type) 355g

[0079] Magnesium Stearate 20g

[0080] 16 grams of absolute ethanol

[0081] A total of 1000 tablets were made, each weighing 1.4 grams.

[0082] Preparation steps: each raw material is passed through an 80-mesh sieve and pulverized; glucosamine sulfate sodium chloride double salt, chondroitin sulfate, starch, microcrystalline cellulose and crospovidone (internal addition type) are placed in a container and fully stirred and mixed Mix well, then add absolute ethanol solution for wetting, pass through 24 mesh to granulate, and dry at 50°C for 60 minutes; add the remaining crospovidone (additional type) and magnesium stearate, and then granulate at 24 mesh; mix well , Determining the con...

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Abstract

The invention relates to the field of pharmacy, particularly a compound glucosamine sulfate dispersible tablet preparation, wherein the main compositions include glucosamine sulfate and chondroitin sulfate, the auxiliary materials include excipient (e.g. starch and microcrystalline cellulose), disintegrating agent (e.g. cross-linked polyplasdone), lubricant (e.g. magnesium stearate) and humectant (e.g. anhydrous alcohol).

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a compound glucosamine sulfate dispersible tablet preparation for treating osteoarthritis and a preparation method thereof. Background technique [0002] Osteoarthritis (OA) is a degenerative joint disease whose incidence increases significantly with age, also known as proliferative arthritis, degenerative arthritis or osteoarthritis. It is the most common cause of joint pain in middle-aged and elderly people, which seriously affects the quality of life of middle-aged and elderly people. [0003] Due to the extension of the average human life expectancy and the aging of the world's population, the medical problems and medical expenses related to OA in countries around the world have also increased sharply, and the social productivity loss and additional economic burden caused by the loss of functions and labor force have also increased sharply. . According to WHO estimates, 10...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K9/20A61K31/7008A61P19/02
Inventor 任金山彭涛杨冬玲赵辉
Owner GUANGZHOU YIPINHONG PHARMA
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