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Powder injection of medium and/or low molecular weight chondroitin sulfate

A technology of chondroitin sulfate and low molecular weight, which is applied in the direction of active ingredients of alkali/alkaline earth metal chlorides, bone diseases, powder delivery, etc. It can solve the problems that chondroitin sulfate is prone to deterioration, affects the quality of drugs, and reduces efficacy, etc., and achieves a solution Deterioration or reduced efficacy, significant pharmacological effects, and effects of increasing shelf life

Inactive Publication Date: 2005-01-12
汤毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, considering that chondroitin sulfate in the injection is prone to deterioration and other phenomena, which will affect the quality of the drug and may cause adverse reactions during the medication process
[0007] Therefore, it is necessary to develop the powder injection of medium and / or low molecular weight chondroitin sulfate. This powder injection can greatly improve the shelf life, thereby completely solving the hidden dangers of deterioration or reduced efficacy during storage and transportation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The formula used in this example is:

[0033] Low molecular weight chondroitin sulfate sodium salt with an average molecular weight of 8,000 3,000g

[0034] Mannitol for injection 1,500g

[0035] Water for injection up to 300,000mL

[0036] The preparation steps used in this embodiment are as follows:

[0037] (1) Weigh the formulated amount of low molecular weight chondroitin sulfate sodium salt and mannitol for injection;

[0038] (2) Dissolve in water for injection;

[0039] (3) Add 0.2% activated carbon, boil for 5 minutes, filter and decarburize;

[0040] (4) Filter the solution obtained in step (4) with a 0.22μm microporous membrane;

[0041] (5) Fill 3mL filtrate in a 10mL control glass bottle;

[0042](6) Freeze-drying, sealing, labeling, packaging, quality inspection, and obtaining freeze-dried powder for injection of low molecular weight chondroitin sulfate sodium salt.

Embodiment 2

[0044] The formula used in this example is:

[0045] Medium molecular weight chondroitin sulfate potassium salt with an average molecular weight of 12,000 3,000g

[0046] Sodium Chloride for Injection 2,700g

[0047] Water for injection up to 300,000mL

[0048] The method of this embodiment is basically the same as the method of embodiment 1, except that in step (1), the formula amount of the medium molecular weight chondroitin sulfate potassium salt and the filler sodium chloride are weighed; finally, the medium molecular weight chondroitin sulfate potassium salt is obtained Lyophilized powder for intravenous injection of salt.

Embodiment 3

[0050] The formula used in this example is:

[0051] Low molecular weight chondroitin sulfate calcium salt with an average molecular weight of 6,000 1,000 g

[0052] The preparation steps used in this embodiment are as follows:

[0053] (1) Dispense 500 mg of low molecular weight chondroitin sulfate calcium salt into 10 mL control glass bottles;

[0054] (2) Sealing, labeling, packaging, quality inspection, and obtaining low-molecular-weight chondroitin sulfate calcium salt injection powder for injection.

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Abstract

The invention discloses a powder injection of medium and / or low molecular weight chondroitin sulfate, in which the average molecular weight of the adopted chondroitin sulfate is in a scope of 2,000-30,000 daltons. The powder injection may be medium and / or low molecular weight chondroitin sulfate A,C or pharmaceutic salt of them, and the powder injection may also contain the its pharmaceutically acceptable auxiliary material. Because the molecular weight of the medium and / or low molecular weight chondroitin sulfate in the inventive powder injection is obviously less than the national standard of the chondroitin sulfate, thus it overcomes shortcoming of big molecular weight fluctuation of the ordinary chondroitin sulfate; it has more notable pharmaceutical role, more helpful for the absorption of the human body; and the powder injection may greatly raise the shelf-life, accordingly thoroughly solving its hidden trouble of going bad or reducing the effect in the storing and transport process.

Description

Technical field [0001] The present invention relates to a powder injection preparation of chondroitin sulfate, in particular to a powder injection preparation of chondroitin sulfate with an average molecular weight in the range of 2,000-30,000 daltons. technical background [0002] Chondroitin sulfate is a kind of macromolecular acid mucopolysaccharide prepared by biochemical extraction technology using cartilage tissue of pigs, cattle, sheep and other animals and cartilage of sharks and other aquatic products as raw materials. The sodium, potassium, calcium and zinc salts of chondroitin sulfate are widely used in medicine, health care products, food, cosmetics, pet feed, etc. Chondroitin sulfate has a variety of physiological functions and plays an important role in maintaining tissue and immune function. It can be used to prevent and treat arthritis, prevent coronary heart disease, treat neuropathic pain such as migraine, and improve senile joint function degradation, etc., esp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/737A61K33/14A61P9/10A61P19/02A61P25/04A61P25/06
Inventor 汤毅
Owner 汤毅
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