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Ophthalmic gel containing chondroitin sulfate and method for preparing same

A chondroitin sulfate and ophthalmic gel technology, which is applied in medical preparations containing active ingredients, medical preparations without active ingredients, and pharmaceutical formulas, etc. Weak external stimuli, etc., to avoid drug loss, simple preparation process, and stable drug release

Active Publication Date: 2009-09-30
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many domestic manufacturers producing compound chondroitin sulfate eye drops (eye drops containing chondroitin sulfate and taurine), but the retention time of the eye drops in the eyes is short, and 70% of them usually overflow from the eyes during use. , so its bioavailability is low
By increasing the viscosity of the drug, the loss of the drug can be improved and the curative effect can be increased. However, the human eye is relatively weak in tolerance to external stimuli, and it is difficult for general excipients to meet the requirements of thickeners for ophthalmic preparations.

Method used

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  • Ophthalmic gel containing chondroitin sulfate and method for preparing same
  • Ophthalmic gel containing chondroitin sulfate and method for preparing same
  • Ophthalmic gel containing chondroitin sulfate and method for preparing same

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] Example 1. Preparation of ophthalmic gel of the present invention

[0029] Composition of ophthalmic gel:

[0030] Component content Chondroitin Sulfate 2.0g Taurine 0.25g Carbomer 4.0g Borax 6.0g Propylene Glycol 5.5g Hydrogenated castor oil 10.0g Ethyl paraben 0.10g Co-made 500 g

[0031] Preparation Process:

[0032] Take prescription amount of carbomer, add appropriate amount of water for injection, swell, and sterilize for use; take appropriate amount of water for injection, add prescription amount of ethyl paraben to dissolve, add borax; take another prescription amount of hydrogenated castor oil, add propylene glycol, Miscible with each other, mix well with the previous step, add to carbomer after 0.22 micron filtration; add the prescription amount of chondroitin sulfate and taurine to dissolve separately, stir evenly, add to carbomer, add water for injection to the full amount , After mixing e...

Embodiment 2

[0033] Example 2. Preparation of ophthalmic gel of the present invention

[0034] Composition of ophthalmic gel:

[0035] Component content Chondroitin Sulfate 2.0g Taurine 0.25g Carbomer 4.5g Sodium hydroxide 4.0g glycerin 4.2g Hydrogenated castor oil 8.0g Benzalkonium chloride 0.12g Co-made 500 g

[0036] Preparation Process:

[0037] Take the prescribed amount of carbomer, add appropriate amount of water for injection, swell, and sterilize for later use; take appropriate amount of water for injection, add the prescription amount of benzalkonium chloride to dissolve, add sodium hydroxide; take another prescription amount of hydrogenated castor oil, add Glycerin, miscible with each other, mix well with the previous step, filter by 0.22 micron and add to the carbomer; take the prescription amount of chondroitin sulfate and taurine to dissolve separately, stir evenly, add to the carbomer, supplement water for...

Embodiment 3

[0038] Example 3. Preparation of ophthalmic gel of the present invention

[0039] Composition of ophthalmic gel:

[0040] Component content Chondroitin Sulfate 2.0g Taurine 0.25g Carbomer 3.5g Hypromellose 1.5g Sodium dihydrogen phosphate 3.5g Mannitol 2.0g Hydrogenated castor oil 10.0g Benzalkonium bromide 0.10g Co-made 500 g

[0041] Preparation Process:

[0042] Take prescription amount of carbomer and hypromellose, add appropriate amount of water for injection, swell, and sterilize for later use; take appropriate amount of water for injection, add prescription amount of benzalkonium bromide to dissolve, add sodium dihydrogen phosphate; take another prescription Add the amount of hydrogenated castor oil, add mannitol, miscible with each other, mix well with the previous step, and add to the carbomer after 0.22 micron filtration; add the prescription amount of chondroitin sulfate and taurine to diss...

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Abstract

The invention relates to an ophthalmic gel containing chondroitin sulfate and a method for preparing the same. The ophthalmic gel comprises chondroitin sulfate and taurine in effective dose and an aqueous gel substrate in proper amount. Compared with eyedrop, the ophthalmic gel has the advantages of good biocompatibility, small stimulation, simple preparation process and the like.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to an ophthalmic gel containing chondroitin sulfate and taurine and a preparation method thereof. Background technique [0002] Chondroitin sulfate is a mucopolysaccharide compound extracted from animal cartilage. It has a protective effect on corneal collagen fibers, promotes the growth of fibers in the matrix, enhances permeability, improves blood circulation, accelerates metabolism, and promotes the absorption of permeate and inflammation. Elimination, promote the healing of corneal wounds. With strong water retention, it can improve the water metabolism of the corneal tissue and improve the symptoms of dry eyes. It can be used for anticoagulation during surgery, and has a good effect on the treatment of trauma, scars and short-scar acne. Used for adhesions after surgery, it has the effects of detoxification, analgesia and promoting wound healing. It can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61K9/00A61K47/38A61P27/02A61K31/185
Inventor 刘继东杨宇春高峨
Owner SHENYANG XINGQI PHARM CO LTD
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