Techniques for heart muscle remodeling using a cardiac pacemaker and related systems and methods

A pacemaker and pacemaker technology, applied in cardiac stimulators, electrotherapy, therapy, etc., can solve problems such as reducing functional capacity

Active Publication Date: 2019-07-02
UNIVERSITY OF VERMONT
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  • Abstract
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  • Claims
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Problems solved by technology

Impaired LV filling and small chamber size reduce functional capacity by limiting cardiac output reserve

Method used

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  • Techniques for heart muscle remodeling using a cardiac pacemaker and related systems and methods
  • Techniques for heart muscle remodeling using a cardiac pacemaker and related systems and methods
  • Techniques for heart muscle remodeling using a cardiac pacemaker and related systems and methods

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Embodiment Construction

[0028] Increasing the heart rate above the normal resting rate can dilate the heart. If the heart rate is elevated substantially and / or over a prolonged period, the subject may develop enlarged heart chambers and / or heart failure. This is a clinical phenotype commonly referred to as tachycardia-induced cardiomyopathy. Alternatively, chamber enlargement can be beneficial if the heart rate is moderately or intermittently elevated. For example, endurance athletes (such as professional cyclists) may increase the size of their chambers to a level considered enlarged. This allows them to increase cardiac output to abnormal levels, thereby increasing their exercise capacity to supraphysiological levels. Because these changes can resolve with inactivity, they are considered benign and have been called athlete's heart. However, subjects with atrial fibrillation with uncontrolled rapid ventricular conduction can also develop similar enlargements in the volume of their heart chambers....

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Abstract

According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute.

Description

Background technique [0001] It is well known that individuals with a sedentary lifestyle and lack of exercise generally have more heart-related health problems than active individuals. A sedentary lifestyle can lead to a reduction in the size of the main chambers of the heart. This can also occur as a result of long-term high blood pressure, which increases muscle thickness, thereby reducing the size of the heart's chambers. Regardless of its cause, reduced cardiac chamber volume reduces stroke volume, which can affect the cardiac output of the heart. Cardiac output limitation greatly reduces exercise capacity. [0002] Heart failure with preserved ejectionfraction (HFpEF) is now the most common cause of heart failure. HFpEF is usually associated with hypertension (HTN), concentric left ventricular hypertrophy (left ventricular hVpertrophV, LVH), reduced left ventricular (left ventricular, LV) chamber size, and increased LV stiffness. Impaired LV filling and small chamber ...

Claims

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Application Information

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IPC IPC(8): A61N1/36A61N1/362A61N1/365A61N1/37A61N1/375
CPCA61N1/3756A61N1/3627A61N1/36542A61N1/36564A61N1/36585A61N1/025
Inventor 马库斯·梅耶尔
Owner UNIVERSITY OF VERMONT
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