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Application of bacillus coagulans to preparing antitumor immunity inducing and immune checkpoint inhibitor sensitizing agents

A technology of Bacillus coagulans and immune checkpoints, which is applied in the field of preparations combined with immune checkpoint inhibitors in the treatment of cancer, can solve problems such as inability to obtain clinical benefits, adverse reactions of the digestive tract, and severe skin itching

Active Publication Date: 2019-07-05
QINGDAO EASTSEA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current medical research believes that continuous treatment of immune checkpoint blockade can bring better therapeutic effect. However, in patients with limited immune checkpoint response, strong side effects such as severe gastrointestinal adverse reactions, severe skin itching, Liver injury, pneumonia, renal impairment, etc. make these patients have to suspend immunotherapy, so that they cannot obtain the expected clinical benefit
[0003] The inventors have found through research that Bacillus coagulans can effectively induce anti-tumor immunity, increase the response rate and therapeutic effect of immune checkpoint inhibitors, reduce side effects, and prolong survival. The effect is better than that of Bifidobacterium, and no relevant research reports have been seen. Special application for this invention patent

Method used

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  • Application of bacillus coagulans to preparing antitumor immunity inducing and immune checkpoint inhibitor sensitizing agents
  • Application of bacillus coagulans to preparing antitumor immunity inducing and immune checkpoint inhibitor sensitizing agents

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preparation Embodiment 1

[0033] Preparation Example 1 The preparation of bacillus coagulans powder

[0034] 1 Preparation of bacteria powder and identification of strains

[0035] Take human feces and other samples, then put the samples in a sterilized bottle, take 2 grams of the samples and add them to 18mL sterilized diluent, mix well, and carry out 10 -1 、10 -2 、10 -3 、10 -4 , 10 -5 , 10 -6 , 10 -7 Gradient dilution, take 10 -5 , 10 -6 , 10 -7 Three dilution gradients, spread on the solid medium for selective single colony isolation of Bacillus coagulans, place in an incubator, culture at 37°C for 48 hours, select a single colony with good growth and inoculate it into the liquid expansion medium of Bacillus coagulans , expanded at 37°C for 48 hours. After the obtained culture solution is centrifuged (12000rpm) to separate the thalline, the thalline is freeze-dried in vacuum to prepare dry bacterial powder, and the number of viable bacteria is 1×10 10 CFU / g or more, then carry out bacteri...

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Abstract

The invention discloses application of bacillus coagulans to preparing antitumor immunity inducing and immune checkpoint inhibitor sensitizing agents. Specifically, the bacillus coagulans is applied as a major active component to preparing biological agents such as drugs and combining with immune checkpoint inhibitor to treat cancers. The prepared antitumor immunity inducing and immune checkpointinhibitor sensitizing agents can effectively induce antitumor immunity, enhance the response and treatment effects of the immune checkpoint inhibitor, reduce side effects and prolong the survival period.

Description

technical field [0001] The present invention relates to the application of bacillus coagulans in the preparation of preparations for inducing anti-tumor immunity and immune checkpoint inhibitor sensitization, in particular, using bacillus coagulans to prepare preparations for inducing anti-tumor immunity and immune checkpoint inhibitor sensitization, and providing the preparation The method for treating cancer with combined immune checkpoint inhibitor belongs to the field of biomedicine. Background technique [0002] Immune checkpoint blockade therapy is currently a hot spot in tumor immunotherapy, CTLA-4 (cytotoxic T lymphocyte-associated antigen), PD-1 (programmed cell death protein 1) and PD-L1 (PD-1 ligand 1) It is a relatively well-studied immune checkpoint molecule at present. Antibodies against these immune checkpoint molecules can block related signaling pathways and enhance endogenous anti-tumor immune effects. These antibody molecules are immune checkpoint inhibito...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/742A61K35/745A61K45/06A61P35/00A61P35/02A23L33/135
CPCA61K35/742A61K35/745A61K45/06A61P35/00A61P35/02A23L33/135A23V2002/00A61K2300/00A23V2200/308
Inventor 崔云龙赵婀姿李洪福
Owner QINGDAO EASTSEA PHARMA
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