Application of methyl myristoleate in preparation of products for preventing or treating metabolic syndromes or improving body energy metabolism

A technology of methyl myristate and metabolic syndrome, applied in the field of biomedicine, can solve problems such as toxic and side effects, and achieve the effect of improving obesity

Active Publication Date: 2019-07-12
INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But it can also cause side effects such as pancreatitis, nausea, and vomiting, and it is especially contraindicated for patients with medullary thyroid cancer and type 2 multiple endocrine neoplasia
Therefore, in view of the fact that the existing obesity therapeutic agents usually have toxic side effects, it has become a research hotspot to find new safe and effective therapeutic agents for the treatment of obesity.

Method used

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  • Application of methyl myristoleate in preparation of products for preventing or treating metabolic syndromes or improving body energy metabolism
  • Application of methyl myristoleate in preparation of products for preventing or treating metabolic syndromes or improving body energy metabolism
  • Application of methyl myristoleate in preparation of products for preventing or treating metabolic syndromes or improving body energy metabolism

Examples

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Embodiment 1

[0029] Construction of genetically obese db / db mouse model.

[0030] 20 genetically obese db / db mice aged 6 weeks were purchased and randomly divided into DB group (10 mice) and DB+ fatty acid group (10 mice).

[0031] The above two groups of mice were treated by intragastric administration.

[0032] Methyl myristate (c14:1) was fed daily to the mice in the DB+fatty acid group at a dose of 5 mg / kg body weight / day, and at the same time the same volume of drinking water containing 1% BSA was fed to the mice in the DB group. The samples were taken after 8 weeks. During this period, they were weighed every week, and indicators such as food intake, exercise, body temperature (rectal temperature), oxygen consumption, and MRI began to be detected from the sixth week. The result is as Figure 1-7 shown. Among them, "DB group" means the group of genetically obese db / db mice fed with drinking water containing 1% BSA in an equal volume, and "DB+ fatty acid group" means that myristico...

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Abstract

The invention provides an application of methyl myristoleate in preparation of products for preventing or treating metabolic syndromes or improving body energy metabolism, wherein the products are medicines, food or health products. A study indicates that methyl myristoleate (c14:1) can activate the thermogenic activity of brown fat (BAT) of hereditary obese db / db mice to consume excess body energy, thereby effectively improving the obesity of the hereditary obese db / db mice.

Description

technical field [0001] The invention belongs to the field of biomedicine. Specifically, the present invention relates to the application of a fatty acid ester in the preparation of products for treating metabolic syndrome or improving body energy metabolism. More specifically, the present invention relates to the unsaturated fatty acid ester represented by formula I - methyl myristoleate (c14:1) (Methyl Myristoleate) in the preparation of products for treating metabolic syndrome or improving energy metabolism of the body Applications. [0002] Background technique [0003] Obesity is a disease that occurs when the body's energy intake exceeds energy expenditure. Obesity first causes insulin resistance, which in turn leads to a series of metabolic disorders such as diabetes, hypertension, hyperlipidemia, atherosclerosis, and cardiovascular and cerebrovascular diseases. As a chronic disease that is a global problem, obesity is a serious disease for which there is current...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/231A61P3/00A61P3/04A61P3/10A61P1/16A61P13/12A61P9/00A61P9/14A61P9/10A61P25/28A61P25/16
CPCA23V2002/00A61K31/231A23L33/115A23V2200/332A23V2200/326A23V2200/328A23V2200/30A23V2250/18
Inventor 金万洙
Owner INST OF ZOOLOGY CHINESE ACAD OF SCI
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