A kind of extraction process of tropane alkaloids

Abstract

The invention discloses a process for extracting scopolane alkaloids, which comprises crushing and leaching the roots of scopolamine from Tibetan medicine scopolamine, and filtering the obtained extract through a ceramic membrane to remove vegetable protein. , colloid, suspended solids and other impurities to obtain ceramic membrane clear liquid, and then pass through ultrafiltration membrane to remove impurities such as small molecular proteins and pigments to obtain ultrafiltration membrane clear liquid, then pass through macroporous adsorption resin to absorb anisodamine , analyzed with ethanol to obtain the desorption solution of the macroporous adsorption resin, and then concentrated through the nanofiltration membrane to obtain the concentrated solution of the nanofiltration membrane containing tropane alkaloids, which is used for evaporation and crystallization in the next step. The invention solves the technical problem that impurities such as suspended solids, colloids and proteins in the extraction process of tropane alkaloids are easily polluted in subsequent macroporous adsorption resins. Compared with the prior art, the present invention has simple equipment process, high degree of automation, simple control process and improved production efficiency and product recovery rate.

Description

technical field [0001] The invention belongs to the field of natural medicine extraction, and in particular relates to an extraction process of tropane alkaloids. Background technique [0002] Anisodus tanguticus (Maxim.) Pascher is a perennial herb of the genus Anisodora in the family Solanaceae. Stems glabrous or puberulent; roots thick, nearly fleshy. Leaf blade papery or nearly firm papery, oblong to narrowly oblong-ovate, apex acute or acuminate, base cuneate or decurrent, with gnawing serrations, both sides glabrous; both sides of petiole slightly winged . Flowers drooping or sometimes erect, calyx bell-shaped or funnel-shaped, firm papery, outside puberulent or nearly glabrous; corolla bell-shaped or funnel-shaped, purple or dark purple, hidden or only the eaves exposed Outside the calyx, the inside of the corolla tube is pilose, the lobes are semicircular; the pistil is slightly longer than the stamen; the flower disc is light yellow. Fruit globose or nearly ovoi...

AI Technical Summary

Problems solved by technology

The wild resources of anisopolamine root in Sichuan are extremely rich, mainly distributed in Ganzi Prefecture and Aba Prefecture. At present, except for the use of local Tibetan medicine as medicinal materials, a large number of resources are not fully utilized

[0006] (1) The amount of organic solvent is large, the cost of raw materials is high, and the organic solvent is not safe. All electrical equipment in the extraction workshop must adopt explosion-proof grades, which greatly increases the cost;

[0007] (2), the use of organic solvent extraction process will introduce new impurities, and the product quality is not high;

[0008] (3), there are many steps, the route is long, and the yield of the product is not high;

[0009] (4) Serious pollution and severe environmental problems

[0010] (5), not suitable for large-scale production, high unit output cost

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