A kind of extraction process of tropane alkaloids

An extraction process and alkaloid technology, applied in the direction of organic chemistry, etc., can solve the problems of unsuitability for large-scale production, underutilization of resources, unsafe organic solvents, etc., achieving a high degree of automation, saving labor costs, and significant economic benefits. Effect

Active Publication Date: 2021-08-06
南京久安源环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The wild resources of anisopolamine root in Sichuan are extremely rich, mainly distributed in Ganzi Prefecture and Aba Prefecture. At present, except for the use of local Tibetan medicine as medicinal materials, a large number of resources are not fully utilized
[0006] (1) The amount of organic solvent is large, the cost of raw materials is high, and the organic solvent is not safe. All electrical equipment in the extraction workshop must adopt explosion-proof grades, which greatly increases the cost;
[0007] (2), the use of organic solvent extraction process will introduce new impurities, and the product quality is not high;
[0008] (3), there are many steps, the route is long, and the yield of the product is not high;
[0009] (4) Serious pollution and severe environmental problems
[0010] (5), not suitable for large-scale production, high unit output cost

Method used

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  • A kind of extraction process of tropane alkaloids
  • A kind of extraction process of tropane alkaloids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] as per figure 1The flow diagram shown for the extraction of tropane alkaloids:

[0036] (1) After crushing the root of Anisodamine, extract it with an acidic aqueous solution with a pH of 2, and the extraction time is 1 hour. Obtain the crude extract of Anisopolamine root;

[0037] (2) After the crude extract that step (1) obtains is filtered through pre-filter (rectangular filter, filtration precision is 1mm), enter microfiltration membrane (microfiltration membrane is ceramic membrane, and filtration precision is 5nm, and filtration temperature is 10°C, the filtration pressure is 0.1MPa) to obtain the microfiltration membrane permeate;

[0038] (3) The microfiltration membrane permeate obtained in step (2) is filtered and decolorized through an ultrafiltration membrane (the ultrafiltration membrane is a roll-type ultrafiltration membrane, the molecular weight cut-off is 1000Da, the filtration temperature is 10°C, and the filtration pressure is 2.5MPa) , after impur...

Embodiment 2

[0043] as per figure 1 The flow diagram shown for the extraction of tropane alkaloids:

[0044] (1) After crushing the root of Anisodamine, extract it with an acidic aqueous solution with a pH of 5, and the extraction time is 6 hours. Obtain the crude extract of Anisopolamine root;

[0045] (2) After the crude extract that step (1) obtains is filtered through pre-filter (rectangular filter, filtration precision is 3mm), enter microfiltration membrane (microfiltration membrane is ceramic membrane, and filtration precision is 500nm, and filtration temperature is 80°C, filtration pressure is 0.8MPa) to obtain microfiltration membrane permeate;

[0046] (3) The microfiltration membrane permeate obtained in step (2) is filtered and decolorized through an ultrafiltration membrane (the ultrafiltration membrane is a roll-type ultrafiltration membrane, the molecular weight cut-off is 20000Da, the filtration temperature is 60°C, and the filtration pressure is 0.5MPa) , after impurity...

Embodiment 3

[0051] as per figure 1 The flow diagram shown for the extraction of tropane alkaloids:

[0052] (1) After crushing the root of Anisodamine, extract it with an acidic aqueous solution with a pH of 3 for 5 hours. Obtain the crude extract of Anisopolamine root;

[0053] (2) After the crude extract that step (1) obtains is filtered through pre-filter (rectangular filter, filtration precision is 5mm), enter microfiltration membrane (microfiltration membrane is ceramic membrane, and filtration precision is 50nm, and filtration temperature is 80°C, the filtration pressure is 0.4MPa) to obtain the microfiltration membrane permeate;

[0054] (3) The microfiltration membrane permeate obtained in step (2) is filtered and decolorized through an ultrafiltration membrane (the ultrafiltration membrane is a roll-type ultrafiltration membrane, the molecular weight cut-off is 10000Da, the filtration temperature is 30°C, and the filtration pressure is 0.5MPa) , after impurity removal, the ult...

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Abstract

The invention discloses a process for extracting scopolane alkaloids, which comprises crushing and leaching the roots of scopolamine from Tibetan medicine scopolamine, and filtering the obtained extract through a ceramic membrane to remove vegetable protein. , colloid, suspended solids and other impurities to obtain ceramic membrane clear liquid, and then pass through ultrafiltration membrane to remove impurities such as small molecular proteins and pigments to obtain ultrafiltration membrane clear liquid, then pass through macroporous adsorption resin to absorb anisodamine , analyzed with ethanol to obtain the desorption solution of the macroporous adsorption resin, and then concentrated through the nanofiltration membrane to obtain the concentrated solution of the nanofiltration membrane containing tropane alkaloids, which is used for evaporation and crystallization in the next step. The invention solves the technical problem that impurities such as suspended solids, colloids and proteins in the extraction process of tropane alkaloids are easily polluted in subsequent macroporous adsorption resins. Compared with the prior art, the present invention has simple equipment process, high degree of automation, simple control process and improved production efficiency and product recovery rate.

Description

technical field [0001] The invention belongs to the field of natural medicine extraction, and in particular relates to an extraction process of tropane alkaloids. Background technique [0002] Anisodus tanguticus (Maxim.) Pascher is a perennial herb of the genus Anisodora in the family Solanaceae. Stems glabrous or puberulent; roots thick, nearly fleshy. Leaf blade papery or nearly firm papery, oblong to narrowly oblong-ovate, apex acute or acuminate, base cuneate or decurrent, with gnawing serrations, both sides glabrous; both sides of petiole slightly winged . Flowers drooping or sometimes erect, calyx bell-shaped or funnel-shaped, firm papery, outside puberulent or nearly glabrous; corolla bell-shaped or funnel-shaped, purple or dark purple, hidden or only the eaves exposed Outside the calyx, the inside of the corolla tube is pilose, the lobes are semicircular; the pistil is slightly longer than the stamen; the flower disc is light yellow. Fruit globose or nearly ovoi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D451/10
CPCC07D451/10
Inventor 张南南陈磊刘怀红李国学方威
Owner 南京久安源环保科技有限公司
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