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Preparation method and application of zinc-baicalin complex

A technology of baicalin and complexes, which is applied in the field of preparation of zinc-baicalin complexes, can solve the problems of many by-products, instability of baicalin, and low yield, so as to reduce the generation of by-products and increase the dissociation rate of hydroxyl groups , the effect of good product purity

Inactive Publication Date: 2019-07-12
WUHAN POLYTECHNIC UNIVERSITY
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Problems solved by technology

This type of synthetic method has the following problems: baicalin is unstable in alkaline solution, and its structure is prone to deterioration, resulting in more by-products in the product, and the binding effect with zinc ions is poor, and the yield is low; Precipitation is easy to occur in alkaline solution, resulting in a decrease in the purity of the product. At the same time, under normal temperature and heating conditions, it is easy to form a colloidal solution when zinc and baicalin are mixed, and it is difficult to form a precipitated product so that the yield of the complex product is low.

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  • Preparation method and application of zinc-baicalin complex
  • Preparation method and application of zinc-baicalin complex

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[0032] In view of this, the present invention proposes a preparation method of the zinc-baicalin complex, which has simple process, easy control, high yield and good product purity. combine figure 1 The schematic flow diagram of an embodiment of the preparation method of the proposed zinc-baicalin complex, the preparation method of the zinc-baicalin complex comprises the following steps:

[0033] Step S10, dissolving the zinc compound in the trimethylamine solution to obtain a zinc ion precursor solution with a pH of 7-8.5.

[0034] Wherein, the zinc compound is Zn(Ac) 2 , ZnCl 2 , ZnSO 4 , Zn(NO 3 ) 2 and ZnC 2 o 4 Any one of them; the mass concentration of the trimethylamine solution is 0.5-1.2%; the mass fraction of zinc in the zinc ion precursor solution is 10-26%.

[0035] In this embodiment, the trimethylamine solution is a solution formed by dissolving trimethylamine in water, and the percentage of the mass of trimethylamine in the solution to the total weight o...

Embodiment 1

[0058] Weigh 2.35g (10.72mmol) Zn(Ac) 2 2H 2 O in a 100ml small beaker, add 0.5% trimethylamine aqueous solution, stir and dissolve to obtain 10%, zinc ion precursor solution of pH7.5;

[0059] Put 3.0 g (6.7 mmol) of baicalin in a 250 ml three-neck flask, add trimethylamine aqueous solution (0.8% by mass fraction), stir and dissolve to form a brownish-yellow clear liquid, and obtain a baicalin solution with a pH of 7;

[0060] The baicalin solution was placed in an ice bath, and under stirring, the zinc ion precursor solution was slowly added dropwise at a speed of 1.0ml / min into the three-neck flask containing the baicalin solution through the addition funnel, and the zinc ions and the baicalin Precipitation occurred immediately after the complex reaction of the glycosides, and after the dropwise addition was completed, stirring was continued for 60 minutes in an ice bath to obtain a mixed solution;

[0061] After the mixed solution was left to stand in an ice bath for 3 h...

Embodiment 2

[0064] Weigh 1.624g (7.4mmol) Zn(Ac) 2 2H 2 O in a 50ml small beaker, add 1.2% trimethylamine aqueous solution, stir and dissolve to obtain 10.8%, pH8.5 zinc ion precursor;

[0065] Put 3.0g (6.7mmol) of baicalin in a 250ml three-necked flask, add trimethylamine aqueous solution (2.6% by mass fraction), stir and dissolve to form a brownish-yellow clear liquid, and obtain a baicalin solution with a pH of 9;

[0066] The baicalin solution is placed in an ice bath, and under stirring, the zinc ion precursor solution is slowly added dropwise at a speed of 2.5ml / min into the three-necked bottle of the baicalin solution through the addition funnel, and the zinc ions and the baicalin Precipitation occurred immediately after the complex reaction of the glycosides, and after the dropwise addition was completed, stirring was continued for 30 minutes in an ice bath to obtain a mixed solution;

[0067] After the mixture was left to stand in an ice bath for 6 hours, the precipitate was o...

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Abstract

The invention discloses a preparation method and application of a zinc-baicalin complex, and relates to the technical field of veterinary drugs. The preparation method of the zinc-baicalin compound comprises the following steps that a zinc compound is dissolved in a trimethylamine solution, and a zinc ion precursor solution with the pH of 7-8.5 is obtained; baicalin is dissolved in an aqueous trimethylamine solution to obtain a baicalin solution with the pH of 7-9; the baicalin solution is placed in an ice bath, under the stirring condition, the zinc ion precursor solution is dropwise added into the baicalin solution, and a mixed solution is obtained through a reaction; the mixed solution is subjected to suction filtration, and a precipitate is obtained, washed and dried to obtain the zinc-baicalin complex. The method aims at increasing the yield of the prepared zinc-baicalin complex and improving the purity of the prepared zinc-baicalin complex.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation method and application of a zinc-baicalin complex. Background technique [0002] Piglet diarrhea is one of the main factors affecting the pig breeding industry. Its pathogenesis is complex, the incidence rate is high, and the mortality rate is high, which seriously affects the healthy development of the pig industry. At present, the most commonly used method for treating piglet diarrhea is to use antibacterial drugs, but there is a problem of strong bacterial resistance. In addition, there are also methods for using Chinese herbal medicine to treat piglet diarrhea. Antibacterial tests in vivo and in vitro have confirmed that the extract of Chinese herbal medicine Scutellaria baicalensis has good antibacterial effects on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Baicalin is the main active ingredient of Scutellaria baicalensis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H23/00C07H1/00A61P1/12A61P31/04A23K20/163A23K50/30A61K31/7135
CPCA61K31/7135A23K20/163A23K50/30A61P1/12A61P31/04C07H1/00C07H23/00
Inventor 寇慧芝程先忠周国庆王洋刘玉兰邱银生
Owner WUHAN POLYTECHNIC UNIVERSITY
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