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Preparation method and application of a magnetically functionalized rare earth fluorescent probe solution

A rare earth fluorescence and magnetic functionalization technology, applied in the field of zinc ion detection, can solve the problems of expensive equipment, high detection limit, complex processing, etc., and achieve the effects of low detection limit, accurate results and simple pretreatment.

Active Publication Date: 2021-08-06
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, it is necessary to provide a magnetically functionalized rare earth fluorescent probe with convenient and accurate results for the detection of zinc ions, so as to solve the technical problems of complex pre-treatment, high detection limit, and expensive equipment for zinc ion detection.

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  • Preparation method and application of a magnetically functionalized rare earth fluorescent probe solution
  • Preparation method and application of a magnetically functionalized rare earth fluorescent probe solution
  • Preparation method and application of a magnetically functionalized rare earth fluorescent probe solution

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Embodiment 1

[0044] Ferric chloride hexahydrate (FeCl 3 ·6H 2 O), terbium nitrate (Tb(NO 3 ) 3 , 99.99%), sodium acetate (NaAc) and ethylene glycol were purchased from Shanghai Aladdin Chemical Reagent Co., Ltd. Guanosine-5'-monophosphate disodium (GMP) was purchased from Beijing Bailingwei Technology Co., Ltd. 4-Hydroxyethylpiperazineethanesulfonic acid (HEPES) and ethanol were purchased from Aladdin Chemical Reagent Co., Ltd. KCl, ZnCl 2 , CaCl 2 , CuCl 2 2H 2 O, Fe(NO 3 ) 3 9H 2 O, Ni(NO 3 ) 2 , Mg(NO 3 ) 2 , Mn(CH 3 COO) 2 , PbCl 2 Purchased from Sinopharm Shanghai Chemical Reagent Co., Ltd. Ultrapure water was prepared by a Milli-Q apparatus (Millipore, Bedford, MA, USA).

[0045] The first step, weigh 2.70g ferric trichloride hexahydrate (FeCl 3 ·6H 2 O) Dissolve in 100mL of ethylene glycol, and ultrasonicate for 5min at room temperature to obtain a yellow transparent liquid. Add 7.20 g of anhydrous sodium acetate, stir at room temperature for 30 min, transfer t...

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Abstract

The invention discloses a preparation method of a magnetically functionalized rare earth fluorescent probe, comprising the following steps: dissolving guanosine-5'-monophosphate disodium solution, Fe 3 o 4 solution, terbium nitrate solution dispersed in 4‑hydroxyethylpiperazineethanesulfonic acid buffer, guanosine‑5'‑monophosphate disodium, Fe 3 o 4 , terbium nitrate, the mass ratio of 4-hydroxyethylpiperazineethanesulfonic acid is (3~8):(0.5~3):(3~18):(1~10), shakes 1~10min, obtains described Magnetically Functionalized Rare Earth Fluorescent Probe Solution GMP / Tb@Fe 3 o 4 . The magnetically functionalized rare earth fluorescent probe for measuring zinc ions prepared by the invention has simple preparation method, mild conditions and easy operation. In the process of detecting zinc ions, the enrichment of zinc ions can be realized by magnetic separation method, using the high sensitivity of fluorescence, the whole process is convenient and the result is accurate.

Description

technical field [0001] The invention belongs to the technical field of zinc ion detection, and in particular relates to a preparation method of a magnetically functionalized rare earth fluorescent probe solution and a method for using the probe to enrich and detect zinc ions in the solution. Background technique [0002] Zinc ions (Zn 2+ ) is one of the essential heavy metals in the human body and plants, and plays an irreplaceable role in key biological macromolecules such as gene transcription proteins and enzymes. Moreover, zinc ions are closely related to the occurrence of a series of diseases, including Alzheimer's disease, stroke and kidney stones. Therefore, it is of great significance to develop a highly sensitive detection method for zinc ions for medical diagnosis and evaluation of the status of biological systems. [0003] Currently common Zn 2+ Detection methods include atomic absorption / emission spectroscopy, electrochemical methods and inductively coupled pl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C08K3/22C09K11/06G01N21/64
CPCC08G83/008C08K3/22C08K2003/2275C08K2201/011C09K11/06C09K2211/182G01N21/6428G01N21/643
Inventor 张磊罗勇泉赵雅梦于博昊张凌怡张维冰
Owner EAST CHINA UNIV OF SCI & TECH