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Quality detection method of paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solution

A quality inspection method and oral solution technology, applied in the field of pharmacy, can solve problems such as the content detection of the substance and artificial bezoar in the oral solution of ammonium ketamine, and achieve safety and effectiveness control, good safety and effectiveness, and increased The effect of control

Inactive Publication Date: 2019-07-16
JIANGXI HEYING PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] In view of this, the main purpose of the present invention is to provide a quality detection method of Ankahuangmin oral solution, which solves the problem that the existing detection method cannot detect the content of related substances and artificial bezoar in the Ankahuangmin oral solution

Method used

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  • Quality detection method of paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solution
  • Quality detection method of paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solution
  • Quality detection method of paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solution

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Embodiment Construction

[0038] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0039] The quality detection method of a kind of Ankahuangmin oral solution provided by the present embodiment, the detection method comprises: the identification of p-aminophenol, p-chlorophenylacetamide and related substances:

[0040] The sample information of the above-mentioned Ankahuangmin Oral Solution is as follows:

[0041]

[0042] The specific identification methods for p-aminophenol, p-chlorophenylacetamide and related substances are as follows:

[0043] 1 test material

[0044] 1.1 Reference substance

[0045] Acetaminophen (batch number: 100018-201610), p-aminophenol (impurity K...

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Abstract

The invention discloses a quality detection method of a paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solution. The quality detection method comprises the steps that p-aminophenol,p-chloroacetanilide, compound calculus bovis, and related substances are identified. According to the quality detection method of the paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oralsolution, fifteen compounds can be detected simultaneously, control of the related substances of the paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solution and the compound calculus bovis is effectively improved, and product safety and effectiveness of the paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solutionare better controlled; and at the same time, theproblem that existing methods can not detect the content of the related substances of the paracetamol, caffeine, cow-bezoar and chlorphenanine maleate oral solutionand the compound calculus bovis issolved.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a quality detection method of a traditional Chinese medicine oral solution, in particular to a quality detection method of an ankahuangmin oral solution. Background technique [0002] Amka Huangmin Oral Solution is mainly used to relieve fever, headache, nasal congestion, sore throat and other symptoms caused by cold or flu in children. [0003] [Ingredients] Prescription (1): Each 1ml contains 12.5mg of paracetamol, 0.75mg of caffeine, 0.15mg of chlorpheniramine maleate, and 0.5mg of artificial bezoar; [0004] Prescription (2): Each 1ml contains acetaminophen 25mg, caffeine 1.5mg, chlorpheniramine maleate 0.3mg, artificial bezoar 1mg [0005] 【Properties】Pale yellow or light brown clear liquid, sweet, slightly bitter, with cooling feeling. [0006] [Usage and Dosage] Prescription (1): Take 0.5 sticks once for children aged 1-4; children aged 5-9, take 1 stick each time; children over 10...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/74G01N21/33
CPCG01N21/33G01N30/02G01N30/74
Inventor 刘均正谭闽怀童猛辉陈有兵聂水金廖园红刘仙辉
Owner JIANGXI HEYING PHARMA CO LTD