Preparation method of bone scaffold having anti-infection characteristic

Abstract

The invention provides a preparation method of a bone scaffold having an anti-infection characteristic. Mesoporous nanometer hydroxylapatite is used as a carrier of vancomycin, high vancomycin load capacity of the mesoporous nanometer hydroxylapatite and functions of the vancomycin for restraining bacterium growth and preventing infection are utilized, anti-infection effects of carboxymethyl chitosan and nanometer silver in various degrees are combined, vancomycin-loaded mesoporous nanometer hydroxylapatite and silver-carboxymethyl chitosan mixed powder is used as a base material, and the bonescaffold having the anti-infection characteristic is prepared through a three-dimensional printed quick shaping technique; and in the preparation course, the scaffold is modified through Type I collagen, and the biocompatibility of the scaffold is improved.

Description

technical field

[0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a preparation method of a bone bracket with anti-infection properties. Background technique

[0002] In the field of orthopedics, bone defects due to severe trauma, bone tumors, osteomyelitis and other reasons are very common. In the process of traumatic bone defect repair, infection is very easy to occur, and the success of bone replacement grafting is closely related to infection. The treatment of infected bone defects has always been a clinical problem in orthopedics because it needs to repair the bone defect and prevent infection. After infection, bacteria form a biofilm on the surface of the implant, which makes the simple bone grafting fail because the infection is not easy to control. Therefore, patients often cannot perform primary bone grafting, but must thoroughly debride the wound. After the infection factors are eliminated, the wound h...

Examples

Embodiment Construction

[0026] Embodiments of the present invention are described in detail below, and the embodiments are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0027] The artificial bone scaffold with anti-infection properties provided by the present invention uses mesoporous nano-hydroxyapatite as the carrier of vancomycin, and utilizes the high vancomycin loading capacity of mesoporous nano-hydroxyapatite and the inhibition of bacterial growth of vancomycin And the function of preventing infection, combined with different degrees of anti-infection effects of carboxymethyl chitosan and nano-silver, based on mesoporous nano-hydroxyapatite and silver-carboxymethyl chitosan mixed powder loaded with vancomycin Materials, using three-dimensional printing rapid prototyping technology to prepare bone scaffolds with anti-infection properties, and modify the scaffolds with type I collagen during the production process to impr...

technical field

[0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a preparation method of a bone bracket with anti-infection properties. Background technique

[0002] In the field of orthopedics, bone defects due to severe trauma, bone tumors, osteomyelitis and other reasons are very common. In the process of traumatic bone defect repair, infection is very easy to occur, and the success of bone replacement grafting is closely related to infection. The treatment of infected bone defects has always been a clinical problem in orthopedics because it needs to repair the bone defect and prevent infection. After infection, bacteria form a biofilm on the surface of the implant, which makes the simple bone grafting fail because the infection is not easy to control. Therefore, patients often cannot perform primary bone grafting, but must thoroughly debride the wound. After the infection factors are eliminated, the wound h...

Examples

Embodiment Construction

[0026] Embodiments of the present invention are described in detail below, and the embodiments are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0027] The artificial bone scaffold with anti-infection properties provided by the present invention uses mesoporous nano-hydroxyapatite as the carrier of vancomycin, and utilizes the high vancomycin loading capacity of mesoporous nano-hydroxyapatite and the inhibition of bacterial growth of vancomycin And the function of preventing infection, combined with different degrees of anti-infection effects of carboxymethyl chitosan and nano-silver, based on mesoporous nano-hydroxyapatite and silver-carboxymethyl chitosan mixed powder loaded with vancomycin Materials, using three-dimensional printing rapid prototyping technology to prepare bone scaffolds with anti-infection properties, and modify the scaffolds with type I collagen during the production process to impr...