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Digestive system malignant tumor marker, and method for preparing drugs for restraining digestive system malignant tumors

A technology for malignant tumors and digestive system, applied in biochemical equipment and methods, anti-tumor drugs, drug combinations, etc., to achieve high sensitivity, strong specificity, and inhibition of proliferation and migration.

Active Publication Date: 2019-07-23
HENAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, the expression of HYAL2 in malignant tumors of the digestive system and its relationship with the occurrence of malignant tumors of the digestive system have not been reported.

Method used

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  • Digestive system malignant tumor marker, and method for preparing drugs for restraining digestive system malignant tumors
  • Digestive system malignant tumor marker, and method for preparing drugs for restraining digestive system malignant tumors
  • Digestive system malignant tumor marker, and method for preparing drugs for restraining digestive system malignant tumors

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Embodiment Construction

[0027] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0028] Interfering with HYAL2 gene expression in the present invention includes knocking out the coding gene of HYAL2, interfering with the transcription or translation of HYAL2 gene, and interfering with the entire biological process of HYAL2 protein function. Although the specific mechanism of the interference is not completely clear, it does not prevent " Interference" is realized.

[0029] In some specific embodiments, the drug can be added with one or more pharmaceutically acceptable adjuva...

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Abstract

The invention belongs to the biopharmaceutical field, and particularly relates to a digestive system malignant tumor marker, and a method for preparing drugs for restraining digestive system malignanttumors. HYAL2 is used for clinical diagnosis of the digestive system malignant tumors, luminescence quantification PCR is used for detecting the expression situation in the digestive system malignanttumors, and according to the expression situation, HYAL2 is used as a molecule maker for the early diagnosis of the digestive system malignant tumors. A carrier for interference HYAL2 gene expressionis constructed for the drugs for restraining the digestive system malignant tumors. The constructed carrier is used for preparing the drugs for in vitro application or in vivo application. Massive experiment data proves that the HYAL2 exerts important adjusting and controlling effects in the generation and development process of the digestive system malignant tumors, the interference HYAL2 gene expression can notably restrain the proliferation and the migration of digestive system malignant tumor cells, and the HYAL2 is hopeful to prepare a new drug for preventing and treating the digestive system malignant tumors.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to a digestive system malignant tumor marker and a method for preparing a drug for inhibiting digestive system malignant tumors. Background technique [0002] With the development of society and economy and the change of dietary structure, the incidence of malignant tumors of the digestive system has increased significantly. The number of deaths caused by malignant tumors of the digestive system accounts for about three quarters of all cancer deaths, which seriously threatens human life and health. Malignant tumors of the digestive system mainly include esophageal cancer, gastric cancer, colorectal cancer, liver cancer, bile duct cancer, and pancreatic cancer. As one of the main systems of the human body, the digestive system has a similar pathophysiological basis for the occurrence of malignant tumors. Although a series of progress has been made in its research, the exact molecular mech...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11A61K31/7105A61P35/00
CPCA61K31/7105A61P35/00C12Q1/6886C12Q2600/158
Inventor 陈卫东聂小博王艳东周云叶文凌
Owner HENAN UNIVERSITY
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