Nicorandil lipid microsphere preparation and preparation method thereof

A technology of nicorandil lipid and nicorandil, which is applied in the field of nicorandil lipid microsphere preparation and preparation thereof, and can solve the problems of low stability of dosage forms and the like
CN110123749AActive Publication Date: 2019-08-16太阳升(亳州)生物医药科技有限公司
8 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
太阳升(亳州)生物医药科技有限公司
Publication Date
2019-08-16

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

An embodiment of the invention provides a Nicorandil lipid microsphere preparation and a preparation method thereof and relates to the field of drug dosage forms, aiming to solve the technical problemthat an existing Nicorandil dosage form is not high in stability. The Nicorandil lipid microsphere preparation comprises Nicorandil, oil for injection, an emulsifier and water for injection, whereinthe Nicorandi is wrapped in the oil for injection in the size of 10-900nm, and the oil for injection is dispersed in the water for injection.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The invention relates to the field of pharmaceutical dosage forms, in particular to a nicorandil lipid microsphere preparation and a preparation method thereof. Background technique

[0002] Nicorandil is a coronary vasodilator used in the treatment of various cardiovascular diseases. It not only has the effect of nitrate ester drugs to expand coronary blood vessels and continuously increase coronary blood flow, but also prevents the release of calcium ions in cells and increases the permeability of cell membranes to potassium ions.

[0003] However, the physical properties of Nicorandil are not stable enough. Nicorandil solid dosage forms are prone to degradation of active drugs when conditions such as humidity, temperature, oxygen, light, acidity, etc. are not suitable. Summary of the invention

[0004] The main purpose of the embodiments of the present invention is to provide a nicorandil lipid microsphere preparation and a preparation method thereof to s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More