Nanostructured solid lipid carrier coating vitamin A palmitate and preparation method thereof

A solid lipid, palmitate technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of vitamin A palmitate being unstable, difficult to penetrate, and poor in dispersion performance. , to achieve the effect of increasing good affinity, promoting penetration and improving adhesion

Inactive Publication Date: 2016-04-20
SHANGHAI INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the objectives of the present invention is to provide a nano-solid lipid coated with vitamin A palmitate in order to solve the above-ment

Method used

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  • Nanostructured solid lipid carrier coating vitamin A palmitate and preparation method thereof
  • Nanostructured solid lipid carrier coating vitamin A palmitate and preparation method thereof
  • Nanostructured solid lipid carrier coating vitamin A palmitate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] A nano-solid lipid carrier coated with vitamin A palmitate, calculated according to the total amount of 100g, its raw material composition and content are as follows:

[0062]

[0063]

[0064] The phospholipid is soybean lecithin with a PC content of 50%, a food-grade product produced by Beijing Meas Phospholipid Technology Co., Ltd.;

[0065] Described solid emulsifier is ceteareth-20;

[0066] Described solid lipid is glyceryl monostearate;

[0067] The liquid lipid is macadamia nut oil;

[0068] Described inorganic salt is sodium chloride;

[0069] The preservative is diazolidinyl urea.

[0070] The above-mentioned nanometer solid lipid carrier coated with vitamin A palmitate specifically comprises the following steps:

[0071] (1) Add vitamin A palmitate, phospholipid, solid lipid, liquid lipid, and solid emulsifier into the container, control the temperature to melt at 70-85°C, and disperse evenly to obtain an oil phase;

[0072] (2) Add inorganic salts...

Embodiment 2

[0076] A nano-solid lipid carrier coated with vitamin A palmitate, calculated according to the total amount of 100g, its raw material composition and content are as follows:

[0077]

[0078] The phospholipid is egg yolk lecithin with a PC content of 70%, a food-grade product produced by Beijing Meas Phospholipid Technology Co., Ltd.;

[0079] Described solid emulsifier is PEG-8 dioleate;

[0080] The solid lipid is cetyl alcohol;

[0081] Described liquid lipid is tridecyl stearate;

[0082] Described inorganic salt is potassium chloride;

[0083] Described preservative is methylparaben.

[0084] The preparation method of the above-mentioned nano solid lipid carrier coated with vitamin A palmitate is the same as in Example 1.

Embodiment 3

[0086] A nano-solid lipid carrier coated with vitamin A palmitate, that is, a nano-solid lipid carrier coated with vitamin A palmitate containing phospholipids, calculated according to the total amount of 100g, its raw material composition and content are as follows:

[0087]

[0088] The phospholipid is soybean lecithin with a PC content of 70%, a food-grade product produced by Shanxi Senfu Natural Products Co., Ltd.;

[0089] Described solid emulsifier is cetearyl glucoside;

[0090] Described solid lipid is hydrogenated castor oil;

[0091] Described liquid lipid is isopropyl palmitate;

[0092] Described inorganic salt is potassium chloride;

[0093] The preservative is propylene glycol-bis-imidazolidinyl urea.

[0094] The above-mentioned nano solid lipid carrier coated with vitamin A palmitate, that is, the preparation method of the nano solid lipid carrier coated with vitamin A palmitate containing phospholipids is the same as that in Example 1.

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Abstract

The invention provides a nanostructured solid lipid carrier coating vitamin A palmitate and a preparation method. The nanostructured solid lipid carrier coating vitamin A palmitate comprises 1-15% of vitamin A palmitate, 0.5-5% of phospholipid, 3-30% of solid emulsifier, 2-15% of solid lipid, 2-10% of liquid lipid, 0.02-1% of inorganic salt, 0.01-0.8% of preservative and the balance of deionized water by weight. The preparation method comprises the following steps: melting and uniformly dispersing vitamin A palmitate, phospholipid, the solid emulsifier, solid lipid and liquid lipid to obtain an oil phase, mixing and heating the inorganic salt and the deionized water to obtain a water phase, adding the oil phase under stirring and adding the preservative after ultrasonic treatment and cooling in sequence, thus obtaining the nanostructured solid lipid carrier coating vitamin A palmitate. The stability and dispersibility of vitamin A palmitate are improved and permeation of vitamin A palmitate on skins is promoted by adopting the nanostructured solid lipid carrier.

Description

technical field [0001] The invention relates to a nano solid lipid carrier coated with vitamin A palmitate and a preparation method thereof, belonging to the field of chemical industry. Background technique [0002] The natural functional ingredient vitamin A palmitate is the esterification product of vitamin A and palmitate. It has the function of vitamins and can be used for the treatment of skin diseases in vitro, such as psoriasis, acne, photoaging and epithelial cancer. Relatively improved stability compared to natural vitamin A. However, it is still easily destroyed after esterification, insoluble in water, ethanol, etc., sensitive to air, light and humidity, and has a melting point of 28-29°C. Therefore, it is unstable when used in preparations, and it is easy to deteriorate during storage and use. At the same time, it has certain irritation, such as redness, peeling and burning sensation after exposure to light. Often through emulsification, coating and other tec...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/67A61K8/55A61Q19/00
CPCA61K8/14A61K8/553A61K8/671A61K2800/10A61Q19/00
Inventor 张婉萍翟晓梅梁小智朱海洋
Owner SHANGHAI INSTITUTE OF TECHNOLOGY
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