Application of amomum tsao-ko essential oil

A technology of grass fruit and essential oil, which is applied in the field of biomedicine to achieve the effects of improving metabolic stability, improving cognitive function, and increasing biological activity

Inactive Publication Date: 2019-08-16
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows us to prepare herbal extract called Grass Fruit Essential Oil which shows potential use against various medical conditions like Parkinson’ s Disease, autism spectrum syndrome, etc., improving their effectiveness at reducing these problems over existing methods without causing harmful side effects

Problems solved by technology

In this patented technical problem addressed in the patented text describes how to develop effective drugs called calcioloo cavae extract(CAS), specifically those containing high amounts of flavonoids like lutearic acid, quercitiessone, carboxylates, alkaloids, amino acids, pepper flakes, ellagitannosides, triterpenes, sterols, fatty alcohols, polyunsaturated oils, etc., through their ability to stimulat rhythmic behavior without causing damage to nerves.

Method used

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  • Application of amomum tsao-ko essential oil
  • Application of amomum tsao-ko essential oil
  • Application of amomum tsao-ko essential oil

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preparation example Construction

[0041] The preparation method of the tsaoko essential oil of the present invention comprises steam distillation extraction and carbon dioxide supercritical extraction.

[0042] Tsaoko essential oil of the present invention is detected by gas chromatography-mass spectrometry instrument, and its component ratio is 1,8-cineole (eucalyptol) (>35%), citral (citral) (>8 %), geraniol (>5%), nerolidol (>1%).

Embodiment 1

[0044] Take 100Kg of dried grass fruit (Amomum tsao-ko Crevost et Lemaire), put it in a heap for 2 days, crush it to 50-mesh coarse particles, soak the coarse particles in 8 times the mass of an aqueous hydrochloric acid solution with a pH value of 5.0, and extract overnight . 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixture into a steam distillation extraction apparatus, reflux extraction at 110°C for 7 hours, collect the distillate, cool it to room temperature, and place it in an oil-water separator for separation. The oil layer is dried with anhydrous sodium sulfate and separated to obtain Tsaoko essential oil.

Embodiment 2

[0046] Take 50Kg of the dried fruit of Amomum tsao-ko Crevost et Lemaire, put it in a heap for 2 days, crush it to 50 mesh coarse particles, soak the coarse particles in 8 times the mass of hydrochloric acid aqueous solution with a pH value of 5.0, and extract overnight . 0.8% cellulase and 0.3% pectinase were added to the extraction mixture by mass percentage, and enzymolysis was carried out at 37° C. for 2.5 hours. Put the above sample and its mixed solution into a carbon dioxide supercritical extraction instrument. The extraction temperature is 46°C, the pressure is 15.70MPa, the time is 85min, and the flow rate of carbon dioxide is 30kg / h; the essential oil is collected and refined in a molecular distillation instrument. The feed temperature is 43°C, the injection speed is 510mL / h, the evaporation temperature of the first stage is 112°C, and the evaporation temperature of the second stage is 63°C, and the part of the second stage distillation is collected to obtain Tsaoko ...

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Abstract

The invention discloses an application of amomum tsao-ko essential oil, an application of the amomum tsao-ko essential oil in preparing drugs for the treatment or prevention of brain dysfunction and other disorder disease and an application of the amomum tsao-ko essential oil in preparing health products for improving brain function and disorder diseases. For the first time, the amomum tsao-ko essential oil is found to have a new use in medicine or large health products that show activity in brain function and disorder diseases of experimental animals, and for the first time, the amommum tsao-ko essential oil or arbitrary components containing the amommum tsao-ko essential oil can improve brain function such as Alzheimer's disease, depression and anxiety in animal body models and the symptoms of disordered animals; compared with traditional medicine for treating the brain function and disorders, the amomum tsao-ko essential oil or the arbitrary components thereof has the mechanism of inhibiting the action of multi-molecular synergy of the cholinesterase and regulating the synergistic action of multiple molecules, such as neurotransmitters, on multiple targets, and is good in drug substitution and easy to penetrate the blood-brain barrier, and the advantages of toxicological safety, stable metabolism, long half-life period and small side effects are achieved.

Description

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Claims

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Application Information

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Owner KUNMING UNIV OF SCI & TECH
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