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Composition with effect of synergistically resisting depression and application

A composition and anti-depressant technology, which is applied in the field of medical medicine, can solve the problems of saikosaponin D’s unstable properties and easy conversion, and achieve the effects of clear material basis of drug efficacy, stable properties, and improved cure rate

Inactive Publication Date: 2019-08-27
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that saikosaponin A and D are the main antidepressant active ingredients of Bupleurum bupleuri, but saikosaponin D is unstable and easily transformed during the decoction process, so the main antidepressant active ingredient may be saikosaponin A

Method used

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  • Composition with effect of synergistically resisting depression and application
  • Composition with effect of synergistically resisting depression and application
  • Composition with effect of synergistically resisting depression and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Such as Figure 1-11 Shown, a kind of composition with synergistic antidepressant effect, described composition comprises saikosaponin A and paeonifloride; The mol ratio of saikosaponin A and paeonifloride in the present embodiment is 1:1, 1:10, 1:20, 1:30, 1:40, 1:50; the single-use concentration of saikosaponin A and paeonifloride glycosides is 50 mg / kg, and the concentration of saikosaponin A and paeonifloride glycosides in combination 50mg / kg+50mg / kg, 25mg / kg+25mg / kg.

[0032] The synergistic antidepressant effect of the composition of the present invention is further verified and evaluated through experiments below.

[0033] 1. In vitro antidepressant activity experiment of saikosaponin A, paeonifloride and the composition of the present invention

[0034] Injury of PC12 cells by corticosterone simulates nerve cell damage caused by hyperactivity of the HPA axis in depression, and investigates the effects of saikosaponin A, paeonifloride and the saikosaponin A and...

Embodiment 2

[0081] A composition with synergistic antidepressant effect, the composition includes saikosaponin A and paeonifloride; the concentration of saikosaponin A of the composition is 10-100 mg / kg, and the concentration of paeonifloride 10-100mg / kg. In this example, the concentrations of saikosaponin A and paeonifloride used alone are 10 mg / kg and 100 mg / kg respectively, and the combined concentrations are 10 mg / kg+100 mg / kg.

[0082] The saikosaponin A, paeonifloride and the composition of the present invention were tested for antidepressant efficacy in vivo using the same in vivo antidepressant efficacy experiment method as in Example 1, and the results are as follows.

[0083] Experimental results

[0084] The results of the mouse tail suspension test are shown in Table 3. The results showed that the immobility time of the paeonifloride group, the composition group and the blank control group were all reduced, and it was statistically significant ( ** P&& P<0.05). The above re...

Embodiment 3

[0094] A composition with synergistic antidepressant effect, the composition includes saikosaponin A and paeonifloride; the concentration of saikosaponin A of the composition is 10-100 mg / kg, and the concentration of paeonifloride 10-100mg / kg. In this example, the concentrations of saikosaponin A and paeonifloride used alone are 100 mg / kg and 10 mg / kg respectively, and the combined concentrations are 100 mg / kg+10 mg / kg.

[0095] The saikosaponin A, paeonifloride and the composition of the present invention were tested for antidepressant efficacy in vivo using the same in vivo antidepressant efficacy experiment method as in Example 1, and the results are as follows.

[0096] Experimental results

[0097] The results of the mouse tail suspension test are shown in Table 5, and the results show that, compared with the blank control group, the saikosaponin group, the composition group, and the blank control group, the immobility time all decreases, and it is statistically signific...

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Abstract

The invention discloses a composition with an effect of synergistically resisting depression and application. The composition contains saikosaponin A and albiflorin; the molar ratio of saikosaponin Aand albiflorin of the composition is 1: (1-50); the concentration of saikosaponin A of the composition is 10 -100 mg / kg; the concentration of albiflorin is 10-100 mg / kg; the composition with the effect of synergistically resisting depression is used to prepare drugs resisting depression. The composition of the invention has the effect of synergistically resisting depression, can improve clinical curing rate of depression, can reduce side effects of application of depression clinical drugs at the same time, and has the characteristics of explicit basis, controllable quality and stable propertyof efficacy substances.

Description

technical field [0001] The invention belongs to the field of medical medicine, and in particular relates to a composition with synergistic antidepressant effect and its application. Background technique [0002] Depression is characterized by persistent low mood and cognitive dysfunction as the main clinical features, and has the characteristics of high prevalence, high recurrence rate, high disability rate and high mortality rate. According to the statistics of the World Health Organization, more than 350 million people worldwide suffer from depression. By 2020, depression may become the second largest disease after heart disease. With the rapid development of social economy and the acceleration of the pace of life, people's pressure increases and various emotional impacts increase, resulting in an increase in the incidence of depression year by year. Depression is called "the epidemic of the 21st century", and its harm has attracted more and more attention from the medica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/24
CPCA61K31/7048A61P25/24A61K2300/00
Inventor 周玉枝李肖秦雪梅张丽增高晓霞田俊生
Owner SHANXI UNIV
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