Traditional Chinese medicine composition for preventing and treating drug-induced liver injury, and preparation method and application thereof

A technology for drug-induced liver injury and a composition is applied in the field of drugs for the prevention and treatment of liver diseases, which can solve the problems of few liver-protecting drugs and large side effects, and achieve the advantages of low prevention and treatment cost, no toxic side effects, good prevention and treatment advantages and development potential. Effect

Inactive Publication Date: 2019-08-27
HEBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, DILI treatment is mainly based on stopping liver-damaging drugs and combined with liver-protecting therapy. There are many types of liver-protecting drugs, but there are not many truly effective liver-protecting drugs, and the side effects are large, and most of them occur after liver damage. Treatment with hepatoprotective drugs

Method used

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  • Traditional Chinese medicine composition for preventing and treating drug-induced liver injury, and preparation method and application thereof
  • Traditional Chinese medicine composition for preventing and treating drug-induced liver injury, and preparation method and application thereof
  • Traditional Chinese medicine composition for preventing and treating drug-induced liver injury, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A traditional Chinese medicine composition for preventing and treating drug-induced liver injury, which is prepared from the following raw materials in parts by weight: 15g of astragalus, 15g of capillary, 15g of salvia miltiorrhiza, 10g of xiangfu, 15g of fried peony root, 15g of Tianjihuang, and 9g of brocade lantern .

[0032] Preparation method: The raw materials used are formula granules produced by Sichuan New Green Pharmaceutical Technology Development Co., Ltd. The formula granules of each drug are mixed according to the above dosage, then soaked in 100-degree pure water, and ultrasonically dissolved to make a medicinal solution.

Embodiment 2

[0034] A traditional Chinese medicine composition for preventing and treating drug-induced liver injury, which is made from the following raw materials: 9g of astragalus, 15g of capillary, 12g of salvia miltiorrhiza, 9g of xiangfu, 10g of fried peony root, 18g of Tianjihuang, 9g of brocade lantern, Bupleurum 6g, Schisandra 2g, fried Atractylodes macrocephala 9g, Scutellaria baicalensis 10g, Mushizi 9g, raw licorice 5g.

[0035] The preparation method is as follows: weighing the crude drug according to the above weight, mixing the weighed crude drug, sterilizing, bagging, decocting and taking it into a decoction.

Embodiment 3

[0037] A traditional Chinese medicine composition for preventing and treating drug-induced liver injury, which is prepared from the following raw materials: 30g of astragalus, 11g of capillary, 15g of salvia miltiorrhiza, 6g of xiangfu, 15g of fried peony root, 25g of Tianjihuang, 6g of brocade lantern, Bupleurum 3g, Schisandra 3g, fried Atractylodes macrocephala 6g, Scutellaria baicalensis 9g, Mushizi 6g, raw licorice 9g.

[0038] The preparation method is as follows: weighing the crude drug according to the above weight, washing and sterilizing the crude drug, pulverizing it into fine powder of 200 mesh to 500 mesh, and packing it into zero-size capsules.

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating drug-induced liver injury, and a preparation method and application thereof, and relates to the technicalfield of medicines for preventing and treating liver diseases. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 9 to 30 parts of radix astragali, 6 to 15 parts of herba artemisiae scopariae, 10 to 15 parts of radix salviae miltiorrhizae, 6 to 10 parts of vinegar-processed rhizoma cyperi, 6 to 15 parts of fried radix paeoniae alba, 15 to30 parts of herba hyperici japonici, 5 to 9 parts of calyx seu fructus physalis, 3 to 10 parts of radix bupleuri, 2 to 6 parts of fructus schisandrae, 6 to 12 parts of fried rhizoma atractylodis macrocephalae, 3 to 10 parts of radix scutellariae, 6 to 12 parts of fructus broussonetiae, and 2 to 10 parts of raw licorice roots. The traditional Chinese medicine composition of the invention is safe,reliable and effective, has no toxic and side effects, has good preventive and therapeutic effects on drug-induced liver injury at low prevention cost, and brings good news for patients with drug-induced liver injury.

Description

technical field [0001] The invention relates to the technical field of drugs for preventing and treating liver diseases. Background technique [0002] Drug-induced liver injury (DILI) is one of the adverse reactions of drugs. With the extensive use of various medicines and various health care products, the incidence of DILI in my country continues to increase. Currently, there are more than 1,000 drugs that may cause DILI. Teng Guangju et al. analyzed 3135 patients who were clearly diagnosed with DILI from January 2002 to December 2011 in the 302nd Hospital of the People’s Liberation Army. 1.39% rose to 3.17% in 2011, an increase of about 2.3 times in 10 years. Foreign studies also show that about 40% of hepatitis and 25% of acute liver failure are caused by drugs. [0003] At present, DILI treatment is mainly based on stopping liver-damaging drugs and combined with liver-protecting therapy. There are many types of liver-protecting drugs, but there are not many truly eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P1/16
CPCA61K36/185A61K36/233A61K36/282A61K36/284A61K36/481A61K36/484A61K36/537A61K36/539A61K36/57A61K36/60A61K36/65A61K36/71A61K36/79A61K36/81A61K36/8905A61P1/16A61K2300/00
Inventor 王茜张一昕郭秋红郝蕾韩雪石铖刘宇
Owner HEBEI UNIV OF CHINESE MEDICINE
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