Application of homoharringtonine in treatment of colorectal tumors

A technology of homoharringtonine and colorectal tumors, which is applied in the field of medicine and drug tumor biology, and can solve the problems of high probability of recurrence and metastasis

Inactive Publication Date: 2019-09-20
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the main treatment for colorectal cancer is a combination of surgery, radiotherapy and chemotherapy, but the probability of recurrence and metastasis is still high

Method used

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  • Application of homoharringtonine in treatment of colorectal tumors
  • Application of homoharringtonine in treatment of colorectal tumors
  • Application of homoharringtonine in treatment of colorectal tumors

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Embodiment Construction

[0021] The present application provides the application of homoharringtonine in the treatment of colorectal tumors.

[0022] The present application provides the application of homoharringtonine in inhibiting the growth of colorectal tumor cells.

[0023] The application provides the application of homoharringtonine in inhibiting the growth of colorectal tumor cells or treating colorectal tumors.

[0024] Further, the dosage form of the medicine includes soft capsule, dropping pill, emulsion, tablet, lotion, liniment, ointment or suppository.

[0025] The application proves that homoharringtonine has inhibitory effect on the growth of colorectal tumor cells and has therapeutic effect on colorectal tumors. Homoharringtonine can not only significantly inhibit the proliferation of two kinds of colorectal tumor cells HT29 and SW620, but also reduce the expression of cyclins CDK2, CDK4, CDK6, CyclinD1, and CyclinE after the treatment of homoharringtonine. After the action, it can...

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Abstract

The application discloses application of homoharringtonine in the treatment of colorectal tumors. Homoharringtonine can inhibit the growth of colorectal tumor cells. It is verified herein that homoharringtonine can inhibit the growth of colorectal tumor cells. Homoharringtonine can inhibit evidently the proliferative abilities of two colorectal tumor cells HT29 and SW620; after homoharringtonine act, the expression of cyclins CDK2, CDK4, CDK6, CyclinD1 and CyclinE is reduced; when acting, homoharringtonine can inhibit the expression of apoptosis inhibitory protein Bcl-2 and promote the expression of apoptosis inhibitory proteins Bax and Cleaved-PARP. It is discovered herein that homoharringtonine can inhibit biological functionality of colorectal tumor cell lines SW620 and HT29; and homoharringtonine can treat colorectal tumors.

Description

technical field [0001] The application relates to the technical field of medicine and drug tumor biology, in particular to the application of homoharringtonine in the treatment of colorectal tumors. Background technique [0002] Colorectal cancer (CRC) is one of the common malignant tumors of the digestive tract, and it is listed as the three most common malignant tumors in the world together with lung cancer and breast cancer. At present, the main treatment for colorectal cancer is a combination of surgery, radiotherapy and chemotherapy, but the probability of recurrence and metastasis is still high. Therefore, actively discovering new targeted therapeutic drugs, researching new therapeutic strategies, and in-depth exploration of pathogenesis are the key areas of our research. [0003] Homoharringtonine (Homoharringtonine, HHT) is one of the anti-tumor alkaloids isolated from the genus Herringtonine in my country. It is a cell cycle-specific drug and has the strongest kill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61K36/13A61P35/00
CPCA61K31/55A61K36/13A61P35/00
Inventor 王立斌曹佳
Owner GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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