A kind of heteropolyvanadate compound and preparation method thereof

Abstract

The invention discloses a heteropolyvanadate compound, the molecular formula is [NH 2 (CH 3 ) 2 ] 12 [(V 5 o 9 Cl) 6 (TATB) 8 ]; The preparation method is: VCl 4 and 4,4,4-triazine-2,4,6-tribenzoic acid were dissolved in 2mL N,N-dimethylformamide and 0.5 mL acetonitrile solution, stirred at room temperature; crystallized at 125~135°C for 40 ~60 hours; cool down, separate green crystals, wash, and dry at room temperature to obtain a heteropolyvanadate compound; the results of in vitro experiments show that the salt is effective on half of SMMC‑7721, MCF‑7, A549, HL‑60 cells The inhibitory concentrations were 0.67 μmol / L, 0.44 μmol / L, 0.48 μmol / L, and 2.09 μmol / L; in vivo experiments showed that the salt could reduce the tumor weight of Hep-A-22 liver cancer-bearing mice.

Description

technical field

[0001] The invention belongs to the technical field of chemical synthesis of drugs, and in particular relates to a heteropolyvanadate compound and a preparation method thereof. Background technique

[0002] In recent years, the incidence of malignant tumors has been increasing year by year, while the age of onset has been decreasing, and the mortality rate is high, seriously endangering human health. According to statistics from the American Cancer Society in September 2018, there were 18.1 million new cancer cases and 9.6 million cancer deaths worldwide. At present, the clinical treatment of tumors mainly adopts surgery, radiotherapy, chemotherapy and other methods, but the side effects of chemotherapy drugs are relatively large; although targeted therapy drugs are sensitive, the problem of drug resistance is very difficult and expensive; the safety of immunotherapy is uncertain. If a cost-effective anti-tumor drug can be developed, it will be a boon for ca...

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