Air pressure supporting type siphon valve structure and centrifugal microfluidic device

Abstract

The invention relates to an air pressure supporting type siphon valve structure and a centrifugal microfluidic device. The air pressure supporting type siphon valve structure comprises a pressurizing chamber and a siphon pipeline, wherein the siphon pipeline comprises a raising pipeline, a transition pipeline and a lowering pipeline which are sequentially connected; the input end of the raising pipeline communicates with a position, far away from a target rotating center, on the pressurizing chamber; the input end of the raising pipeline also communicates with a sample feeding chamber; and the output end of the lowering pipeline communicates with a collecting chamber. According to the air pressure supporting type siphon valve structure and the centrifugal microfluidic device, air pressure is creatively used for replacing capillary force to drive liquid to flow in direction opposite to the centrifugal force direction, thus high-speed centrifugal sealing effect can be achieved, and moreover, a valve is driven by air pressure to open while low-speed rotating is realized; the effect of the siphon valve is realized in centrifugal microfluidic control through the balance of the air pressure and the centrifugal force; in addition, the inner surface of the siphon pipeline is prevented from hydrophilic treatment, and hydrophilic materials are saved, so that the processing technology of a microfluidic control chip and processing quality control cost are greatly simplified.

Description

technical field [0001] The present application relates to the field of centrifugal microfluidics, in particular to an air pressure assisted siphon valve structure and a centrifugal microfluidic device. Background technique [0002] Microfluidics refers to the manipulation of liquids on the submillimeter scale. It integrates the basic operating units involved in the fields of biology and chemistry, and even integrates the functions of the entire laboratory, including sampling, dilution, reaction, separation, detection, etc., on a small chip, so it is also called Lab-on-a-Chip (Lab-on-a-Chip). -a-Chip). This kind of chip is generally composed of various liquid storage pools and interconnected microchannel networks, which can greatly shorten the sample processing time, and realize the maximum utilization efficiency of reagent consumables through precise control of liquid flow. Microfluidics provides extremely broad prospects for applications in many fields such as biomedical ...

AI Technical Summary

Problems solved by technology

These processing methods often greatly increase the difficulty of making microfluidic chips, and increase the cost of mass production and quality control of microfluidic chips.

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