A 3D printing composite bio-ink material and its preparation method and application

A bio-ink and 3D printing technology, applied in the field of 3D bio-printing, can solve the problems of poor interface bonding between matrix and filler, unfavorable polymer matrix coating, and degradation of material mechanical properties, so as to achieve improved interface bonding, good application prospects, and improved The effect of mechanical properties
CN110302419BActive Publication Date: 2022-01-14JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2022-01-14

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Abstract

The invention discloses a 3D printing composite bio-ink material as well as a preparation method and application thereof. The composition of the composite biological ink material includes biodegradable polyester, reinforcing and toughening agent and ternary solvent system. Wherein, the ternary solvent system contains 40-90% of organic solvent, 5-45% of surfactant and 5-45% of plasticizer by mass percentage. Compared with a single low-boiling-point organic solvent system, the ternary solvent system not only improves the printability of the composite bioink, but also improves the interfacial bonding between the biodegradable polyester matrix and the reinforcing toughener, and enhances the printing process. The interfacial bonding between the middle fiber layer and the layer can endow the 3D printed composite porous scaffold with good three-dimensional structure and mechanical properties. In addition, the reinforced and toughening agent used can further improve the mechanical properties and osteogenic activity of the biodegradable polyester, endowing the composite porous scaffold with excellent ability to promote bone tissue repair.
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Description

technical field

[0001] The invention belongs to the technical field of 3D bioprinting, and in particular relates to a 3D printing composite bioink material and its preparation method and application. Background technique

[0002] Bone defects caused by congenital diseases, trauma, tumors and surgery are the most common and frequent clinical diseases, and the treatment of bone defects has always been the main problem faced by reconstructive surgery. There are many technologies reported in the literature for constructing porous scaffolds for bone tissue engineering, but 3D printing, which stands out in recent years, has attracted much attention because of its outstanding advantages. 3D printing is based on the computer three-dimensional design model, using laser guidance, inkjet printing and other technologies to build up and bond biological materials layer by layer, superimpose and shape them, and finally form simulated tissues or organs. 3D printing can flexibly construct s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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