Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method of 2-chloro-5-methoxypyrimidine

A technology of methoxypyrimidine and toluene, which is applied in the field of compound preparation, can solve the problems of low product yield, high cost, complicated method of 2-chloro-5-methoxypyrimidine, etc., and achieve high product purity and mild reaction , easy-to-control effects

Pending Publication Date: 2019-10-15
SUZHOU RYAN PHARMACHEM TECH CO LTD
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The traditional method for preparing 2-chloro-5-methoxypyrimidine is complex, high in cost and low in yield

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of 2-chloro-5-methoxypyrimidine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and preferred embodiments.

[0013] As shown in the figure, the present invention comprises the following steps:

[0014] a. the compound shown in preparation formula B:

[0015] Put 3.5L of toluene and 850g of sodium methoxide into a 10L reaction flask, cool down to 10°C with ice water, and add 606g of methyl formate dropwise. Since the boiling point of methyl formate is low, keep the temperature of the reaction solution lower than 20°C, after the dropwise addition, stir for 30 minutes;

[0016] Then add 750g of methyl methoxyacetate dropwise. During the dropwise addition, the temperature of the reaction solution is lower than 30°C. After the dropwise addition is completed, stir for 5-6 hours. After the stirring is completed, let stand overnight; ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of compound preparation methods, and in particular relates to a preparation method of 2-chloro-5-methoxypyrimidine, which is prepared by taking methyl methoxyacetateas a raw material. The product prepared by the preparation method has high purity, the catalyst and the solvent can be recycled, the reaction is mild, the control is easy, and the method is suitablefor industrial production.

Description

technical field [0001] The invention relates to the field of compound preparation methods, in particular to a preparation method of 2-chloro-5-methoxypyrimidine. Background technique [0002] The traditional method for preparing 2-chloro-5-methoxypyrimidine is complex, high in cost and low in yield Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the deficiencies in the prior art and provide a preparation method of 2-chloro-5-methoxypyrimidine. [0004] The present invention is achieved through the following technical solutions: [0005] A preparation method of 2-chloro-5-methoxypyrimidine is characterized in that it comprises the following steps: [0006] a. Preparation of the compound shown in formula B: put toluene and sodium methoxide into a reaction flask, cool down to 10°C in ice water, add methyl formate dropwise, keep the temperature below 20°C during the dropwise addition, and stir after the dropwise a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D239/34
CPCC07D239/34
Inventor 夏青青江涛张明张路路
Owner SUZHOU RYAN PHARMACHEM TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com