Transdermal patch of clonidine hydrochloride and preparation method thereof

A technology of clonidine hydrochloride and transdermal patch, which is applied in anti-inflammatory agents, medical equipment, and pharmaceutical formulas, and can solve problems such as permeability and unsatisfactory administration time, so as to improve the smoothness of medication, optimize the course of medication, The effect of strengthening crystal growth

Inactive Publication Date: 2019-10-22
苏州盈得来医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem that the existing transdermal patch has insufficient permeability and administration time, the present invention provides a transdermal patch of clonidine hydrochloride and a preparation method, the purpose of which is to improve the permeability and adhesion of the drug and improve the drug administration. Medicine duration

Method used

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  • Transdermal patch of clonidine hydrochloride and preparation method thereof
  • Transdermal patch of clonidine hydrochloride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A transdermal patch of clonidine hydrochloride, the patch includes a backing layer and a paste layer, the backing layer includes an identification code with a unique code, and the identification code includes a product display information module, a user text And / or photo information entry module, the paste layer includes 7wt% clonidine hydrochloride, 4wt% triethylamine, 4wt% diethanolamine, 0.3wt% antioxidant 1010, 64wt% TPE-S resin , 20wt% terpene resin. The preparation method of aforementioned transdermal patch, described preparation method comprises the steps:

[0030] 1) Prepare the raw materials of each component according to the aforementioned paste components, dissolve TPE-S resin and terpene resin in acetone, and add clonidine hydrochloride, triethylamine, diethanolamine and antioxidant 1010 to the solution to Ultrasonic treatment with 1200w power for 30min.

[0031] 2) Treat the solution obtained in step 1) with a power of 200w for 5 minutes, apply the mixed ...

Embodiment 2

[0034] A transdermal patch of clonidine hydrochloride, the patch includes a backing layer and a paste layer, the backing layer includes an identification code with a unique code, and the identification code includes a product display information module, a user text And / or photo information entry module, the paste layer includes 10wt% clonidine hydrochloride, 4wt% triethylamine, 5.2wt% diethanolamine, 0.5wt% vitamin E, 60wt% TPE-S resin, 20 wt% terpene resin. The preparation method of aforementioned transdermal patch, described preparation method comprises the steps:

[0035] 1) Prepare the raw materials of each component according to the aforementioned paste components, dissolve TPE-S resin and terpene resin in acetone, add clonidine hydrochloride, triethylamine, diethanolamine and antioxidant to the solution respectively, and use 1000w Ultrasonic treatment with high power for 45min.

[0036] 2) Treat the solution obtained in step 1) with a power of 300w for 3 minutes, apply...

Embodiment 3

[0039] A transdermal patch of clonidine hydrochloride, the patch includes a backing layer and a paste layer, the backing layer includes an identification code with a unique code, and the identification code includes a product display information module, a user text And / or photo information entry module, the paste layer includes 15wt% clonidine hydrochloride, 5wt% triethylamine, 6.5wt% diethanolamine, 0.6wt% vitamin E, 58wt% TPE-S resin, 14.9 wt% terpene resin. The preparation method of aforementioned transdermal patch, described preparation method comprises the steps:

[0040] 1) Prepare the raw materials of each component according to the aforementioned paste components, dissolve TPE-S resin and terpene resin in acetone, add clonidine hydrochloride, triethylamine, diethanolamine and antioxidant to the solution respectively, and use 1100w Ultrasonic treatment with high power for 40min.

[0041] 2) Treat the solution obtained in step 1) with a power of 300w for 3 minutes, app...

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Abstract

The invention provides a transdermal patch of clonidine hydrochloride. The patch comprises a liner layer and a paste layer, wherein the liner layer comprises an identification code with a unique code,the identification code comprises a product display information module and a user text and / or photo information input module, the paste layer is prepared from, by weight, 5-15% of clonidine hydrochloride, 2-5% of triethylamine, 3-7% of diethanol amine, 0.3-0.6% of an antioxidant, 42-64% of TPE-S resin and 10-22% of terpene resin, wherein the mass ratio of the triethylamine to the diethanol amineis (1:1)-(1:1.3), and the mass ratio of the TPE-S resin to the terpene resin is (3:1)-(4.5:1). The transdermal patch can effectively improve the smoothness of medication for patients through the management of the Internet of Things, and can optimize the subsequent medication treatment course through the management of the Internet of Things.

Description

technical field [0001] The invention relates to a transdermal plaster and a preparation method thereof, in particular to a clonidine hydrochloride transdermal patch and a preparation method thereof. Background technique [0002] Clonidine hydrochloride, chemical name is 2_[(2,6-dichlorophenyl) imino] imidazolidine hydrochloride, molecular formula: C 9 h 9 C 12 N 3 ·Molecular weight of HCl: 266.56 Clonidine hydrochloride directly stimulates the central post-synaptic membrane of the hypothalamus and medulla 2 Receptors excite inhibitory neurons, reduce central sympathetic impulse efferents, and thereby inhibit peripheral sympathetic activity. Clonidine hydrochloride tablets, prescription drugs. It is mainly used for the treatment of high blood pressure, hypertensive emergencies, migraine, ADHD, menopausal hot flashes, dysmenorrhea, and symptoms of opioid addiction withdrawal. [0003] Transdermal patches are a new type of drug that absorbs through the skin through capill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4168A61K47/18A61P9/12A61P25/06A61P25/14A61P15/00A61P29/00A61P25/36G06K17/00G16H40/67G16H20/10G16H50/70H04L29/08
CPCA61K9/7023A61K9/0014A61K47/18A61K31/4168A61P9/12A61P25/06A61P25/14A61P15/00A61P29/00A61P25/36G06K17/0022G16H40/67G16H20/10G16H50/70H04L67/12
Inventor 陈伟强中泽肖钢
Owner 苏州盈得来医药科技有限公司
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